Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis

Kyoung Jin Park; Dong Hyun Kim; Chung Sub Kim; Joonseok Oh; Lalita Subedi; Mi Won Son; Sang Zin Choi; Sun Yeou Kim; Kang Ro Lee

doi:10.1016/j.tetlet.2018.10.057

Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis

Kyoung Jin Park
, Dong Hyun Kim
, Chung Sub Kim
, Joonseok Oh
, Lalita Subedi
, Mi Won Son
, Sang Zin Choi
, Sun Yeou Kim
, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4–15). The structures of the new compounds (1–3) were determined through spectroscopic methods. The absolute configuration of 1 was confirmed further by electronic circular dichroism (ECD) data analysis and computational method with advanced statistics (DP4). All isolated compounds (1–15) were evaluated for their potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.

Original language	English
Pages (from-to)	4380-4383
Number of pages	4
Journal	Tetrahedron Letters
Volume	59
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2018.10.057
State	Published - 12 Dec 2018

Keywords

Anthranilic acid
DP4
Indigo Pulverata Levis
Indole alkaloid
Neuroprotection

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10.1016/j.tetlet.2018.10.057

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title = "Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis",

abstract = "A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4–15). The structures of the new compounds (1–3) were determined through spectroscopic methods. The absolute configuration of 1 was confirmed further by electronic circular dichroism (ECD) data analysis and computational method with advanced statistics (DP4). All isolated compounds (1–15) were evaluated for their potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.",

keywords = "Anthranilic acid, DP4, Indigo Pulverata Levis, Indole alkaloid, Neuroprotection",

author = "Park, \{Kyoung Jin\} and Kim, \{Dong Hyun\} and Kim, \{Chung Sub\} and Joonseok Oh and Lalita Subedi and Son, \{Mi Won\} and Choi, \{Sang Zin\} and Kim, \{Sun Yeou\} and Lee, \{Kang Ro\}",

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doi = "10.1016/j.tetlet.2018.10.057",

language = "English",

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TY - JOUR

T1 - Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis

AU - Park, Kyoung Jin

AU - Kim, Dong Hyun

AU - Kim, Chung Sub

AU - Oh, Joonseok

AU - Subedi, Lalita

AU - Son, Mi Won

AU - Choi, Sang Zin

AU - Kim, Sun Yeou

AU - Lee, Kang Ro

PY - 2018/12/12

Y1 - 2018/12/12

N2 - A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4–15). The structures of the new compounds (1–3) were determined through spectroscopic methods. The absolute configuration of 1 was confirmed further by electronic circular dichroism (ECD) data analysis and computational method with advanced statistics (DP4). All isolated compounds (1–15) were evaluated for their potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.

AB - A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4–15). The structures of the new compounds (1–3) were determined through spectroscopic methods. The absolute configuration of 1 was confirmed further by electronic circular dichroism (ECD) data analysis and computational method with advanced statistics (DP4). All isolated compounds (1–15) were evaluated for their potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.

KW - Anthranilic acid

KW - DP4

KW - Indigo Pulverata Levis

KW - Indole alkaloid

KW - Neuroprotection

UR - https://www.scopus.com/pages/publications/85055906558

U2 - 10.1016/j.tetlet.2018.10.057

DO - 10.1016/j.tetlet.2018.10.057

M3 - Article

AN - SCOPUS:85055906558

SN - 0040-4039

VL - 59

SP - 4380

EP - 4383

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis

Abstract

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