Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

Chung Sub Kim; Lalita Subedi; Oh Kil Kwon; Sun Yeou Kim; Eui Ju Yeo; Sang Un Choi; Kang Ro Lee

doi:10.1016/j.bmcl.2015.12.004

Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

Chung Sub Kim, Lalita Subedi, Oh Kil Kwon, Sun Yeou Kim, Eui Ju Yeo, Sang Un Choi, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (¹H and ¹³C NMR, ¹H-¹H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.

Original language	English
Pages (from-to)	351-354
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2015.12.004
State	Published - 15 Jan 2016

Keywords

Anti-inflammation
Biphenyl compounds
Chaenomeles sinensis
Cytotoxicity
NGF-potentiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2015.12.004

Cite this

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title = "Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis",

abstract = "Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (1H and 13C NMR, 1H-1H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.",

keywords = "Anti-inflammation, Biphenyl compounds, Chaenomeles sinensis, Cytotoxicity, NGF-potentiation",

author = "Kim, \{Chung Sub\} and Lalita Subedi and Kwon, \{Oh Kil\} and Kim, \{Sun Yeou\} and Yeo, \{Eui Ju\} and Choi, \{Sang Un\} and Lee, \{Kang Ro\}",

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doi = "10.1016/j.bmcl.2015.12.004",

language = "English",

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T1 - Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

AU - Kim, Chung Sub

AU - Subedi, Lalita

AU - Kwon, Oh Kil

AU - Kim, Sun Yeou

AU - Yeo, Eui Ju

AU - Choi, Sang Un

AU - Lee, Kang Ro

PY - 2016/1/15

Y1 - 2016/1/15

N2 - Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (1H and 13C NMR, 1H-1H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.

AB - Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (1H and 13C NMR, 1H-1H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.

KW - Anti-inflammation

KW - Biphenyl compounds

KW - Chaenomeles sinensis

KW - Cytotoxicity

KW - NGF-potentiation

UR - https://www.scopus.com/pages/publications/84952889346

U2 - 10.1016/j.bmcl.2015.12.004

DO - 10.1016/j.bmcl.2015.12.004

M3 - Article

C2 - 26706168

AN - SCOPUS:84952889346

SN - 0960-894X

VL - 26

SP - 351

EP - 354

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

Abstract

Keywords

UN SDGs

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