Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

Chung Sub Kim; Lalita Subedi; Oh Kil Kwon; Sun Yeou Kim; Eui Ju Yeo; Sang Un Choi; Kang Ro Lee

doi:10.1016/j.bmcl.2015.12.004

Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

Chung Sub Kim
, Lalita Subedi
, Oh Kil Kwon
, Sun Yeou Kim
, Eui Ju Yeo
, Sang Un Choi
, Kang Ro Lee

Department of Pharmacy

Gachon University
Sungkyunkwan University
Korea Research Institute of Chemical Technology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (¹H and ¹³C NMR, ¹H-¹H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.

Original language	English
Pages (from-to)	351-354
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2015.12.004
State	Published - 15 Jan 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-inflammation
Biphenyl compounds
Chaenomeles sinensis
Cytotoxicity
NGF-potentiation

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10.1016/j.bmcl.2015.12.004

Cite this

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title = "Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis",

abstract = "Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (1H and 13C NMR, 1H-1H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.",

keywords = "Anti-inflammation, Biphenyl compounds, Chaenomeles sinensis, Cytotoxicity, NGF-potentiation",

author = "Kim, \{Chung Sub\} and Lalita Subedi and Kwon, \{Oh Kil\} and Kim, \{Sun Yeou\} and Yeo, \{Eui Ju\} and Choi, \{Sang Un\} and Lee, \{Kang Ro\}",

year = "2016",

month = jan,

day = "15",

doi = "10.1016/j.bmcl.2015.12.004",

language = "English",

volume = "26",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

AU - Kim, Chung Sub

AU - Subedi, Lalita

AU - Kwon, Oh Kil

AU - Kim, Sun Yeou

AU - Yeo, Eui Ju

AU - Choi, Sang Un

AU - Lee, Kang Ro

PY - 2016/1/15

Y1 - 2016/1/15

N2 - Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (1H and 13C NMR, 1H-1H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.

AB - Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (1H and 13C NMR, 1H-1H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.

KW - Anti-inflammation

KW - Biphenyl compounds

KW - Chaenomeles sinensis

KW - Cytotoxicity

KW - NGF-potentiation

UR - https://www.scopus.com/pages/publications/84952889346

U2 - 10.1016/j.bmcl.2015.12.004

DO - 10.1016/j.bmcl.2015.12.004

M3 - Article

C2 - 26706168

AN - SCOPUS:84952889346

SN - 0960-894X

VL - 26

SP - 351

EP - 354

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

Abstract

UN SDGs

Keywords

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