TY - JOUR
T1 - Irreversible inhibition of zinc-containing protease by oxazolidinone derivatives. Novel inactivation chemistry
AU - Kim, Dong H.
AU - Chung, Sang Jeon
AU - Kim, Eun Jung
AU - Tian, Guan Rong
PY - 1998/4/7
Y1 - 1998/4/7
N2 - α-Benzyl-2-oxo-1,3-oxazolidine-4-acetic acid (BOOA) having (αR,4S) and (αS,4R) configurations were designed and synthesized as a novel type of mechanism-based inactivators for carboxypeptidase A (CPA), and kinetic analysis demonstrated that they indeed inhibit the enzyme in a time-dependent manner with the second order inhibitory rate constants (k(inact)/K(I)) of 1.52 and 1.39 M-1 s-1 for (αS,4R)-BOOA and (αR,4S)-BOOA, respectively.
AB - α-Benzyl-2-oxo-1,3-oxazolidine-4-acetic acid (BOOA) having (αR,4S) and (αS,4R) configurations were designed and synthesized as a novel type of mechanism-based inactivators for carboxypeptidase A (CPA), and kinetic analysis demonstrated that they indeed inhibit the enzyme in a time-dependent manner with the second order inhibitory rate constants (k(inact)/K(I)) of 1.52 and 1.39 M-1 s-1 for (αS,4R)-BOOA and (αR,4S)-BOOA, respectively.
UR - https://www.scopus.com/pages/publications/0032492702
U2 - 10.1016/S0960-894X(98)00123-1
DO - 10.1016/S0960-894X(98)00123-1
M3 - Article
C2 - 9871555
AN - SCOPUS:0032492702
SN - 0960-894X
VL - 8
SP - 859
EP - 864
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 7
ER -