Irradiative damage characterization of a lysozyme during high-power THz ablation using MALDI-TOF mass spectrometry

  • K. H. Eom
  • , S. E. Peltek
  • , V. M. Popik
  • , Y. U. Jeong
  • , O. S. Kwon
  • , W. Y. Park
  • , W. S. Lee
  • , J. H. So
  • , G. S. Park

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

High-power pulsed THz waves which are generated by free electron laser near 2.2 THz are found to induce the nondestructive ablation of lysozyme. The peak electric field strength exposed on the sample is estimated over 10 kV/cm. The aerosol phase nanoparticles (ablated lysozyme) size is measured using real-time condensation particle counter, and the ablated lysozyme is analyzed using MALDI-TOF mass spectrometry to characterize irradiative damage during THz ablation process. The mass spectrum of ablated lysozyme shows no difference with control, but the sample remaining on the substrate shows thermal oxidation. These results confirm the nondestructive THz ablation of lysozyme; they suggest possible THz biological application such as mass spectrometry or electrospray using high-power pulsed THz waves.

Original languageEnglish
Title of host publicationIRMMW-THz 2012 - 37th International Conference on Infrared, Millimeter, and Terahertz Waves
DOIs
StatePublished - 2012
Externally publishedYes
Event37th International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2012 - Wollongong, NSW, Australia
Duration: 23 Sep 201228 Sep 2012

Publication series

NameInternational Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
ISSN (Print)2162-2027
ISSN (Electronic)2162-2035

Conference

Conference37th International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2012
Country/TerritoryAustralia
CityWollongong, NSW
Period23/09/1228/09/12

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