Abstract
Background: The metabolism of host lipids is central to the survival of intracellular Mtb. Results: Degradation of cholesterol generates propionyl-CoA, which is, in part, detoxified through incorporation into methylbranched lipids. Conclusion: The balance of acetyl-CoA versus propionyl-CoA concentrations in Mtb impacts detoxification of propionyl-CoA. Significance: The ability of Mtb to utilize host-derived lipids effectively is key to its success as a pathogen.
| Original language | English |
|---|---|
| Pages (from-to) | 6788-6800 |
| Number of pages | 13 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 10 |
| DOIs | |
| State | Published - 8 Mar 2013 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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