Abstract
The nigrosome 1 and 4 regions in the substantia nigra can be assessed separately by using high-spatial-resolution susceptibility map-weighted imaging. The nigrosome 1 region is mainly identified below the red nucleus, while the nigrosome 4 region is located at the level of the lower portion of the red nucleus on coronal-reformatted susceptibility map-weighted imaging. Each region exhibits differential involvement according to clinical stages in idiopathic Parkinson’s disease, with the nigrosome 1 region involved earlier, followed by the nigrosome 4 region. Such observations may be supported by coregistered high-spatial-resolution neuromelanin-sensitive imaging and the relationship with the extent of abnormality of dopamine transporter activity. From our results, we suggest that high-spatial-resolution susceptibility map-weighted imaging may serve not only as a diagnostic tool but also as an imaging biomarker for disease severity in idiopathic Parkinson’s disease.
| Original language | English |
|---|---|
| Title of host publication | Genetics, Neurology, Behavior, and Diet in Parkinson’s Disease |
| Subtitle of host publication | The Neuroscience of Parkinson’s Disease, Volume 2 |
| Publisher | Elsevier |
| Pages | 267-281 |
| Number of pages | 15 |
| ISBN (Electronic) | 9780128159507 |
| DOIs | |
| State | Published - 1 Jan 2020 |
| Externally published | Yes |
Keywords
- Dopamine transporter imaging
- Magnetic resonance imaging
- Neuromelanin-sensitive imaging
- Nigrosome
- Quantitative susceptibility mapping
- Substantia nigra