TY - JOUR
T1 - Insights into the Vastly Different Effects of Eutectic Solvents on the Stability of Phenolic Compounds
AU - Kang, Seulgi
AU - Namgoong, Hyun
AU - Son, Woo Sung
AU - Kim, Yong Doo
AU - Jeong, Kyung Min
AU - Jin, Yan
AU - Won, Hyung Sik
AU - Hong, Jongki
AU - Jeong, Jihoon
AU - Lee, Jeongmi
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/7/2
Y1 - 2020/7/2
N2 - Eutectic solvents (ESs) have shown stabilizing effects on several molecules. Due to the potential applicability of bioactive compounds, understanding how ESs stabilize them is of great interest in pharmaceutical and related fields. Here, among various ESs, CTU, which comprise thiourea and choline chloride (ChCl), exerted remarkably high stabilizing effects on various phenolic compounds, whereas CU consisting of urea and ChCl exhibited the opposite effects. Using a potent polyphenol, (-)-epigallocatechin gallate (EGCG), as a model compound, we conducted experimental and in silico studies to unravel the underlying mechanisms of the two very similar ESs for the contrasting effects. The results suggest that ESs can affect with great diversity the stability of EGCG by complicated interactions arising from the unique properties of both ESs and their components.
AB - Eutectic solvents (ESs) have shown stabilizing effects on several molecules. Due to the potential applicability of bioactive compounds, understanding how ESs stabilize them is of great interest in pharmaceutical and related fields. Here, among various ESs, CTU, which comprise thiourea and choline chloride (ChCl), exerted remarkably high stabilizing effects on various phenolic compounds, whereas CU consisting of urea and ChCl exhibited the opposite effects. Using a potent polyphenol, (-)-epigallocatechin gallate (EGCG), as a model compound, we conducted experimental and in silico studies to unravel the underlying mechanisms of the two very similar ESs for the contrasting effects. The results suggest that ESs can affect with great diversity the stability of EGCG by complicated interactions arising from the unique properties of both ESs and their components.
UR - https://www.scopus.com/pages/publications/85087533526
U2 - 10.1021/acs.jpclett.0c00610
DO - 10.1021/acs.jpclett.0c00610
M3 - Article
C2 - 32525682
AN - SCOPUS:85087533526
SN - 1948-7185
VL - 11
SP - 5268
EP - 5272
JO - Journal of Physical Chemistry Letters
JF - Journal of Physical Chemistry Letters
IS - 13
ER -