Innovative Approach to Detecting Autism Spectrum Disorder Using Explainable Features and Smart Web Application

Autism Spectrum Disorder (ASD) is a complex developmental condition marked by challenges in social interaction, communication, and behavior, often involving restricted interests and repetitive actions. The diversity in symptoms and skill profiles across individuals creates a diagnostic landscape that requires a multifaceted approach for accurate understanding and intervention. This study employed advanced machine-learning techniques to enhance the accuracy and reliability of ASD diagnosis. We used a standard dataset comprising 1054 patient samples and 20 variables. The research methodology involved rigorous preprocessing, including selecting key variables through data mining (DM) visualization techniques including Chi-Square tests, analysis of variance, and correlation analysis, along with outlier removal to ensure robust model performance. The proposed DM and logistic regression (LR) with Shapley Additive exPlanations (DMLRS) model achieved the highest accuracy at 99%, outperforming state-of-the-art methods. eXplainable artificial intelligence was incorporated using Shapley Additive exPlanations to enhance interpretability. The model was compared with other approaches, including XGBoost, Deep Models with Residual Connections and Ensemble (DMRCE), and fast lightweight automated machine learning systems. Each method was fine-tuned, and performance was verified using k-fold cross-validation. In addition, a real-time web application was developed that integrates the DMLRS model with the Django framework for ASD diagnosis. This app represents a significant advancement in medical informatics, offering a practical, user-friendly, and innovative solution for early detection and diagnosis.