Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

Hyung Min Kim; Joon Ho Lee; Jin Hee Won; Eun Jeung Park; Han Jung Chae; Hyung Ryong Kim; Cheorl Ho Kim; Seung Hwa Baek

doi:10.1002/ptr.749

Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

Hyung Min Kim, Joon Ho Lee, Jin Hee Won, Eun Jeung Park, Han Jung Chae, Hyung Ryong Kim, Cheorl Ho Kim, Seung Hwa Baek

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.

Original language	English
Pages (from-to)	572-576
Number of pages	5
Journal	Phytotherapy Research
Volume	15
Issue number	7
DOIs	https://doi.org/10.1002/ptr.749
State	Published - 2001
Externally published	Yes

Keywords

Compositae
IgE
Immunization
Siegesbeckia glabrescens
U266 human IgE-bearing B cells

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ptr.749

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title = "Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens",

abstract = "Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.",

keywords = "Compositae, IgE, Immunization, Siegesbeckia glabrescens, U266 human IgE-bearing B cells",

author = "Kim, \{Hyung Min\} and Lee, \{Joon Ho\} and Won, \{Jin Hee\} and Park, \{Eun Jeung\} and Chae, \{Han Jung\} and Kim, \{Hyung Ryong\} and Kim, \{Cheorl Ho\} and Baek, \{Seung Hwa\}",

year = "2001",

doi = "10.1002/ptr.749",

language = "English",

volume = "15",

pages = "572--576",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

AU - Kim, Hyung Min

AU - Lee, Joon Ho

AU - Won, Jin Hee

AU - Park, Eun Jeung

AU - Chae, Han Jung

AU - Kim, Hyung Ryong

AU - Kim, Cheorl Ho

AU - Baek, Seung Hwa

PY - 2001

Y1 - 2001

N2 - Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.

AB - Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.

KW - Compositae

KW - IgE

KW - Immunization

KW - Siegesbeckia glabrescens

KW - U266 human IgE-bearing B cells

UR - https://www.scopus.com/pages/publications/0034766193

U2 - 10.1002/ptr.749

DO - 10.1002/ptr.749

M3 - Article

C2 - 11746835

AN - SCOPUS:0034766193

SN - 0951-418X

VL - 15

SP - 572

EP - 576

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 7

ER -

Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

Abstract

Keywords

UN SDGs

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