Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity

Hee Jeong Eom; Yong Joo Park; Hee Rae Kang; Ha Ryong Kim; In Jae Bang; Hyun Bong Park; Kyu Hyuck Chung; Ki Hyun Kim

doi:10.3329/bjp.v11i3.26776

Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity

Hee Jeong Eom
, Yong Joo Park
, Hee Rae Kang
, Ha Ryong Kim
, In Jae Bang
, Hyun Bong Park
, Kyu Hyuck Chung
, Ki Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Sphagnum palustre (a moss) has been traditionally used in Korea for the cure of several diseases such as cardiac pain and stroke. In this research, the inhibitory effect of S. palustre on aromatase (cytochrome P450 19, CYP19) activity was studied. [1ǃ-3H] androstenedione was used as a substrate and incubated with S. palustre extract and recombinant human CYP19 in the presence of NADPH. S. palustre extract inhibited aromatase in a concentration-dependent manner (IC₅₀ value: 36.4 ± 8.1 µg/mL). To elucidate the major compounds responsible for the aromatase inhibitory effects of S. palustre extract, nine compounds were isolated from the extract and tested for their inhibition of aromatase activity. Compounds 1, 6, and 7 displayed aromatase inhibition, while the inhibition by the other compounds was negligible.

Original language	English
Pages (from-to)	661-665
Number of pages	5
Journal	Bangladesh Journal of Pharmacology
Volume	11
Issue number	3
DOIs	https://doi.org/10.3329/bjp.v11i3.26776
State	Published - 2016

Keywords

Aromatase activity
Moss
Sphagnum palustre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3329/bjp.v11i3.26776

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title = "Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity",

abstract = "Sphagnum palustre (a moss) has been traditionally used in Korea for the cure of several diseases such as cardiac pain and stroke. In this research, the inhibitory effect of S. palustre on aromatase (cytochrome P450 19, CYP19) activity was studied. [1ǃ-3H] androstenedione was used as a substrate and incubated with S. palustre extract and recombinant human CYP19 in the presence of NADPH. S. palustre extract inhibited aromatase in a concentration-dependent manner (IC50 value: 36.4 ± 8.1 µg/mL). To elucidate the major compounds responsible for the aromatase inhibitory effects of S. palustre extract, nine compounds were isolated from the extract and tested for their inhibition of aromatase activity. Compounds 1, 6, and 7 displayed aromatase inhibition, while the inhibition by the other compounds was negligible.",

keywords = "Aromatase activity, Moss, Sphagnum palustre",

author = "Eom, \{Hee Jeong\} and Park, \{Yong Joo\} and Kang, \{Hee Rae\} and Kim, \{Ha Ryong\} and Bang, \{In Jae\} and Park, \{Hyun Bong\} and Chung, \{Kyu Hyuck\} and Kim, \{Ki Hyun\}",

year = "2016",

doi = "10.3329/bjp.v11i3.26776",

language = "English",

volume = "11",

pages = "661--665",

journal = "Bangladesh Journal of Pharmacology",

issn = "1991-007X",

publisher = "Bangladesh Pharmacological Society",

number = "3",

}

TY - JOUR

T1 - Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity

AU - Eom, Hee Jeong

AU - Park, Yong Joo

AU - Kang, Hee Rae

AU - Kim, Ha Ryong

AU - Bang, In Jae

AU - Park, Hyun Bong

AU - Chung, Kyu Hyuck

AU - Kim, Ki Hyun

PY - 2016

Y1 - 2016

N2 - Sphagnum palustre (a moss) has been traditionally used in Korea for the cure of several diseases such as cardiac pain and stroke. In this research, the inhibitory effect of S. palustre on aromatase (cytochrome P450 19, CYP19) activity was studied. [1ǃ-3H] androstenedione was used as a substrate and incubated with S. palustre extract and recombinant human CYP19 in the presence of NADPH. S. palustre extract inhibited aromatase in a concentration-dependent manner (IC50 value: 36.4 ± 8.1 µg/mL). To elucidate the major compounds responsible for the aromatase inhibitory effects of S. palustre extract, nine compounds were isolated from the extract and tested for their inhibition of aromatase activity. Compounds 1, 6, and 7 displayed aromatase inhibition, while the inhibition by the other compounds was negligible.

AB - Sphagnum palustre (a moss) has been traditionally used in Korea for the cure of several diseases such as cardiac pain and stroke. In this research, the inhibitory effect of S. palustre on aromatase (cytochrome P450 19, CYP19) activity was studied. [1ǃ-3H] androstenedione was used as a substrate and incubated with S. palustre extract and recombinant human CYP19 in the presence of NADPH. S. palustre extract inhibited aromatase in a concentration-dependent manner (IC50 value: 36.4 ± 8.1 µg/mL). To elucidate the major compounds responsible for the aromatase inhibitory effects of S. palustre extract, nine compounds were isolated from the extract and tested for their inhibition of aromatase activity. Compounds 1, 6, and 7 displayed aromatase inhibition, while the inhibition by the other compounds was negligible.

KW - Aromatase activity

KW - Moss

KW - Sphagnum palustre

UR - https://www.scopus.com/pages/publications/84978645981

U2 - 10.3329/bjp.v11i3.26776

DO - 10.3329/bjp.v11i3.26776

M3 - Article

AN - SCOPUS:84978645981

SN - 1991-007X

VL - 11

SP - 661

EP - 665

JO - Bangladesh Journal of Pharmacology

JF - Bangladesh Journal of Pharmacology

IS - 3

ER -

Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity

Abstract

Keywords

UN SDGs

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