Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells

Jae Youl Cho; Jisoo Park; Eun Sook Yoo; Kazuko Yoshikawa; Kyong Up Baik; Jongsoo Lee; Myung Hwan Park

doi:10.1007/BF03216746

Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells

Jae Youl Cho, Jisoo Park, Eun Sook Yoo, Kazuko Yoshikawa, Kyong Up Baik, Jongsoo Lee, Myung Hwan Park

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The inhibitory effect of 10 lignan constituents isolated from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor (TNF)-α production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, woorenoside-V and lariciresinol glycoside showed significant inhibitory activities in the range from 37% to 55% at the concentration of 25 μg/ml. The results are first report that the lignans isolated from Coptis japonica inhibit TNF-α production, and suggest that the lignan components may partly participate in antiinflammatory and antiallergic effect of Coptis japonica through the inhibition of TNF-α production.

Original language	English
Pages (from-to)	12-16
Number of pages	5
Journal	Archives of Pharmacal Research
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/BF03216746
State	Published - Feb 1998
Externally published	Yes

Keywords

Coptis japonica
ELISA
Lariciresinol glycoside
Lignan
LPS
Pinoresinol
RAW264.7
TNF-α
Woorenoside

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10.1007/BF03216746

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title = "Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells",

abstract = "The inhibitory effect of 10 lignan constituents isolated from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor (TNF)-α production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, woorenoside-V and lariciresinol glycoside showed significant inhibitory activities in the range from 37\% to 55\% at the concentration of 25 μg/ml. The results are first report that the lignans isolated from Coptis japonica inhibit TNF-α production, and suggest that the lignan components may partly participate in antiinflammatory and antiallergic effect of Coptis japonica through the inhibition of TNF-α production.",

keywords = "Coptis japonica, ELISA, Lariciresinol glycoside, Lignan, LPS, Pinoresinol, RAW264.7, TNF-α, Woorenoside",

author = "Cho, \{Jae Youl\} and Jisoo Park and Yoo, \{Eun Sook\} and Kazuko Yoshikawa and Baik, \{Kyong Up\} and Jongsoo Lee and Park, \{Myung Hwan\}",

year = "1998",

month = feb,

doi = "10.1007/BF03216746",

language = "English",

volume = "21",

pages = "12--16",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

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TY - JOUR

T1 - Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells

AU - Cho, Jae Youl

AU - Park, Jisoo

AU - Yoo, Eun Sook

AU - Yoshikawa, Kazuko

AU - Baik, Kyong Up

AU - Lee, Jongsoo

AU - Park, Myung Hwan

PY - 1998/2

Y1 - 1998/2

N2 - The inhibitory effect of 10 lignan constituents isolated from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor (TNF)-α production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, woorenoside-V and lariciresinol glycoside showed significant inhibitory activities in the range from 37% to 55% at the concentration of 25 μg/ml. The results are first report that the lignans isolated from Coptis japonica inhibit TNF-α production, and suggest that the lignan components may partly participate in antiinflammatory and antiallergic effect of Coptis japonica through the inhibition of TNF-α production.

AB - The inhibitory effect of 10 lignan constituents isolated from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor (TNF)-α production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, woorenoside-V and lariciresinol glycoside showed significant inhibitory activities in the range from 37% to 55% at the concentration of 25 μg/ml. The results are first report that the lignans isolated from Coptis japonica inhibit TNF-α production, and suggest that the lignan components may partly participate in antiinflammatory and antiallergic effect of Coptis japonica through the inhibition of TNF-α production.

KW - Coptis japonica

KW - ELISA

KW - Lariciresinol glycoside

KW - Lignan

KW - LPS

KW - Pinoresinol

KW - RAW264.7

KW - TNF-α

KW - Woorenoside

UR - https://www.scopus.com/pages/publications/0031987931

U2 - 10.1007/BF03216746

DO - 10.1007/BF03216746

M3 - Article

C2 - 9875508

AN - SCOPUS:0031987931

SN - 0253-6269

VL - 21

SP - 12

EP - 16

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 1

ER -

Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells

Abstract

Keywords

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