Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells

Jongyeob Choi; Minwha Jo; Eunyoung Lee; Dooseok Choi

doi:10.1016/j.fertnstert.2010.06.006

Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells

Jongyeob Choi
, Minwha Jo
, Eunyoung Lee
, Dooseok Choi

Department of Obstetrics and Gynecology

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation.

Original language	English
Pages (from-to)	1482-1486
Number of pages	5
Journal	Fertility and Sterility
Volume	95
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2010.06.006
State	Published - 15 Mar 2011

Keywords

Apoptosis
autophagy
bcl-2
caspases
granulosa cell

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10.1016/j.fertnstert.2010.06.006

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@article{566d59228960482f96df5604c34a38e6,

title = "Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells",

abstract = "This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation.",

keywords = "Apoptosis, autophagy, bcl-2, caspases, granulosa cell",

author = "Jongyeob Choi and Minwha Jo and Eunyoung Lee and Dooseok Choi",

year = "2011",

month = mar,

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doi = "10.1016/j.fertnstert.2010.06.006",

language = "English",

volume = "95",

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T1 - Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells

AU - Choi, Jongyeob

AU - Jo, Minwha

AU - Lee, Eunyoung

AU - Choi, Dooseok

PY - 2011/3/15

Y1 - 2011/3/15

N2 - This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation.

AB - This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation.

KW - Apoptosis

KW - autophagy

KW - bcl-2

KW - caspases

KW - granulosa cell

UR - https://www.scopus.com/pages/publications/79952441038

U2 - 10.1016/j.fertnstert.2010.06.006

DO - 10.1016/j.fertnstert.2010.06.006

M3 - Article

C2 - 20630503

AN - SCOPUS:79952441038

SN - 0015-0282

VL - 95

SP - 1482

EP - 1486

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells

Abstract

Keywords

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