Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

Hak Cheol Kwon; Byeong Gon Lee; Seung Hee Kim; Chil Mann Jung; Sung Youl Hong; Jeung Whan Han; Hyang Woo Lee; Ok Pyo Zee; Kang Ro Lee

doi:10.1007/BF02979067

Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

Hak Cheol Kwon, Byeong Gon Lee, Seung Hee Kim, Chil Mann Jung, Sung Youl Hong, Jeung Whan Han, Hyang Woo Lee, Ok Pyo Zee, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.

Original language	English
Pages (from-to)	410-413
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	22
Issue number	4
DOIs	https://doi.org/10.1007/BF02979067
State	Published - Aug 1999

Keywords

4,8-Dimethoxy-1-vinyl-β-carboline
4-Methoxy-1-vinyl-carboline
Inducible nitric oxide synthase
Melia azedarach var. japonica

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10.1007/BF02979067

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title = "Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica",

abstract = "In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.",

keywords = "4,8-Dimethoxy-1-vinyl-β-carboline, 4-Methoxy-1-vinyl-carboline, Inducible nitric oxide synthase, Melia azedarach var. japonica",

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year = "1999",

month = aug,

doi = "10.1007/BF02979067",

language = "English",

volume = "22",

pages = "410--413",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

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}

TY - JOUR

T1 - Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

AU - Kwon, Hak Cheol

AU - Lee, Byeong Gon

AU - Kim, Seung Hee

AU - Jung, Chil Mann

AU - Hong, Sung Youl

AU - Han, Jeung Whan

AU - Lee, Hyang Woo

AU - Zee, Ok Pyo

AU - Lee, Kang Ro

PY - 1999/8

Y1 - 1999/8

N2 - In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.

AB - In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.

KW - 4,8-Dimethoxy-1-vinyl-β-carboline

KW - 4-Methoxy-1-vinyl-carboline

KW - Inducible nitric oxide synthase

KW - Melia azedarach var. japonica

UR - https://www.scopus.com/pages/publications/0033173268

U2 - 10.1007/BF02979067

DO - 10.1007/BF02979067

M3 - Article

C2 - 10489883

AN - SCOPUS:0033173268

SN - 0253-6269

VL - 22

SP - 410

EP - 413

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 4

ER -

Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

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