Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

Hak Cheol Kwon; Byeong Gon Lee; Seung Hee Kim; Chil Mann Jung; Sung Youl Hong; Jeung Whan Han; Hyang Woo Lee; Ok Pyo Zee; Kang Ro Lee

doi:10.1007/BF02979067

Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

Hak Cheol Kwon
, Byeong Gon Lee
, Seung Hee Kim
, Chil Mann Jung
, Sung Youl Hong
, Jeung Whan Han
, Hyang Woo Lee
, Ok Pyo Zee
, Kang Ro Lee

Department of Pharmacy

Sungkyunkwan University
Food and Drug Administration of Korea

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.

Original language	English
Pages (from-to)	410-413
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	22
Issue number	4
DOIs	https://doi.org/10.1007/BF02979067
State	Published - Aug 1999

Keywords

4,8-Dimethoxy-1-vinyl-β-carboline
4-Methoxy-1-vinyl-carboline
Inducible nitric oxide synthase
Melia azedarach var. japonica

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10.1007/BF02979067

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title = "Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica",

abstract = "In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.",

keywords = "4,8-Dimethoxy-1-vinyl-β-carboline, 4-Methoxy-1-vinyl-carboline, Inducible nitric oxide synthase, Melia azedarach var. japonica",

author = "Kwon, \{Hak Cheol\} and Lee, \{Byeong Gon\} and Kim, \{Seung Hee\} and Jung, \{Chil Mann\} and Hong, \{Sung Youl\} and Han, \{Jeung Whan\} and Lee, \{Hyang Woo\} and Zee, \{Ok Pyo\} and Lee, \{Kang Ro\}",

year = "1999",

month = aug,

doi = "10.1007/BF02979067",

language = "English",

volume = "22",

pages = "410--413",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

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}

TY - JOUR

T1 - Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

AU - Kwon, Hak Cheol

AU - Lee, Byeong Gon

AU - Kim, Seung Hee

AU - Jung, Chil Mann

AU - Hong, Sung Youl

AU - Han, Jeung Whan

AU - Lee, Hyang Woo

AU - Zee, Ok Pyo

AU - Lee, Kang Ro

PY - 1999/8

Y1 - 1999/8

N2 - In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.

AB - In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.

KW - 4,8-Dimethoxy-1-vinyl-β-carboline

KW - 4-Methoxy-1-vinyl-carboline

KW - Inducible nitric oxide synthase

KW - Melia azedarach var. japonica

UR - https://www.scopus.com/pages/publications/0033173268

U2 - 10.1007/BF02979067

DO - 10.1007/BF02979067

M3 - Article

C2 - 10489883

AN - SCOPUS:0033173268

SN - 0253-6269

VL - 22

SP - 410

EP - 413

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 4

ER -

Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

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