In vivo Evaluation of PEEK Copolymer Composites for Prosthetic Spine

Joon Woo Chon; Yang Xin; Seung Mook Lee; Young Jun Kim; In Sung Jeon; Jae Young Jho; Dong June Chung

doi:10.1007/s13233-021-9027-2

In vivo Evaluation of PEEK Copolymer Composites for Prosthetic Spine

Joon Woo Chon, Yang Xin, Seung Mook Lee, Young Jun Kim, In Sung Jeon, Jae Young Jho, Dong June Chung

SKKU Advanced Institute of Nano Technology (SAINT)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In this study, we evaluated the biosafety of a novel polyetheretherketone (PEEK) copolymer [P(E2-E4)K] composite using an animal model to test an implanted orthopedic spine cage. The PEEK copolymer was synthesized by solution polymerization with diphenyl sulfone solvent and blended with carbon fibers and graphene oxide to produce the composite. The P(E2-E4)K composite exhibited improved mechanical properties, similar to natural bone. The animal study results for short-term inflammation evaluation by hematoxylin & eosin and immunostaining methods showed significant histochemical stability for 3 weeks after implantation, demonstrating the required biosafety for medical application as an implantable spine cage.[Figure not available: see fulltext.]

Original language	English
Pages (from-to)	244-251
Number of pages	8
Journal	Macromolecular Research
Volume	29
Issue number	3
DOIs	https://doi.org/10.1007/s13233-021-9027-2
State	Published - Mar 2021

Keywords

in vivo biosafety
PEEK composite
PEEK copolymer synthesis
spine cage application

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title = "In vivo Evaluation of PEEK Copolymer Composites for Prosthetic Spine",

abstract = "In this study, we evaluated the biosafety of a novel polyetheretherketone (PEEK) copolymer [P(E2-E4)K] composite using an animal model to test an implanted orthopedic spine cage. The PEEK copolymer was synthesized by solution polymerization with diphenyl sulfone solvent and blended with carbon fibers and graphene oxide to produce the composite. The P(E2-E4)K composite exhibited improved mechanical properties, similar to natural bone. The animal study results for short-term inflammation evaluation by hematoxylin \& eosin and immunostaining methods showed significant histochemical stability for 3 weeks after implantation, demonstrating the required biosafety for medical application as an implantable spine cage.[Figure not available: see fulltext.]",

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author = "Chon, \{Joon Woo\} and Yang Xin and Lee, \{Seung Mook\} and Kim, \{Young Jun\} and Jeon, \{In Sung\} and Jho, \{Jae Young\} and Chung, \{Dong June\}",

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year = "2021",

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doi = "10.1007/s13233-021-9027-2",

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T1 - In vivo Evaluation of PEEK Copolymer Composites for Prosthetic Spine

AU - Chon, Joon Woo

AU - Xin, Yang

AU - Lee, Seung Mook

AU - Kim, Young Jun

AU - Jeon, In Sung

AU - Jho, Jae Young

AU - Chung, Dong June

PY - 2021/3

Y1 - 2021/3

N2 - In this study, we evaluated the biosafety of a novel polyetheretherketone (PEEK) copolymer [P(E2-E4)K] composite using an animal model to test an implanted orthopedic spine cage. The PEEK copolymer was synthesized by solution polymerization with diphenyl sulfone solvent and blended with carbon fibers and graphene oxide to produce the composite. The P(E2-E4)K composite exhibited improved mechanical properties, similar to natural bone. The animal study results for short-term inflammation evaluation by hematoxylin & eosin and immunostaining methods showed significant histochemical stability for 3 weeks after implantation, demonstrating the required biosafety for medical application as an implantable spine cage.[Figure not available: see fulltext.]

AB - In this study, we evaluated the biosafety of a novel polyetheretherketone (PEEK) copolymer [P(E2-E4)K] composite using an animal model to test an implanted orthopedic spine cage. The PEEK copolymer was synthesized by solution polymerization with diphenyl sulfone solvent and blended with carbon fibers and graphene oxide to produce the composite. The P(E2-E4)K composite exhibited improved mechanical properties, similar to natural bone. The animal study results for short-term inflammation evaluation by hematoxylin & eosin and immunostaining methods showed significant histochemical stability for 3 weeks after implantation, demonstrating the required biosafety for medical application as an implantable spine cage.[Figure not available: see fulltext.]

KW - in vivo biosafety

KW - PEEK composite

KW - PEEK copolymer synthesis

KW - spine cage application

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DO - 10.1007/s13233-021-9027-2

M3 - Article

AN - SCOPUS:85103545673

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JO - Macromolecular Research

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In vivo Evaluation of PEEK Copolymer Composites for Prosthetic Spine

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Keywords

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