In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica

Jae Youl Cho; Kyong Up Baik; Eun Sook Yoo; K. Yoshikawa; Myung Hwan Park

doi:10.1021/np9902791

In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica

Jae Youl Cho
, Kyong Up Baik
, Eun Sook Yoo
, K. Yoshikawa
, Myung Hwan Park

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-α and nitric oxide (NO) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.

Original language	English
Pages (from-to)	1205-1209
Number of pages	5
Journal	Journal of Natural Products
Volume	63
Issue number	9
DOIs	https://doi.org/10.1021/np9902791
State	Published - 2000
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np9902791

Cite this

@article{6c3777dcc9d94a8c85808bfb3483b608,

title = "In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica",

abstract = "Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-α and nitric oxide (NO) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.",

author = "Cho, \{Jae Youl\} and Baik, \{Kyong Up\} and Yoo, \{Eun Sook\} and K. Yoshikawa and Park, \{Myung Hwan\}",

year = "2000",

doi = "10.1021/np9902791",

language = "English",

volume = "63",

pages = "1205--1209",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica

AU - Cho, Jae Youl

AU - Baik, Kyong Up

AU - Yoo, Eun Sook

AU - Yoshikawa, K.

AU - Park, Myung Hwan

PY - 2000

Y1 - 2000

N2 - Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-α and nitric oxide (NO) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.

AB - Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-α and nitric oxide (NO) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.

UR - https://www.scopus.com/pages/publications/0033797335

U2 - 10.1021/np9902791

DO - 10.1021/np9902791

M3 - Article

C2 - 11000020

AN - SCOPUS:0033797335

SN - 0163-3864

VL - 63

SP - 1205

EP - 1209

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this