In situ observation of hydroxyapatite nanocrystal formation from amorphous calcium phosphate in calcium-rich solutions

Sujin Kim; Hyun Seung Ryu; Hyunho Shin; Hyun Suk Jung; Kug Sun Hong

doi:10.1016/j.matchemphys.2004.12.016

In situ observation of hydroxyapatite nanocrystal formation from amorphous calcium phosphate in calcium-rich solutions

Sujin Kim, Hyun Seung Ryu, Hyunho Shin, Hyun Suk Jung, Kug Sun Hong

Seoul National University

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

The formation of hydroxyapatite (HAp) from amorphous calcium phosphate (ACP) was in situ observed in calcium-rich aqueous solutions (Ca/P molar ratios were 1.67, 1.83, and 2.0) by freeze-drying the precipitates withdrawn at selected time intervals during the reaction. As the more excess calcium ions exist in the solution, the HAp crystallization from ACP occurred more rapidly and the Ca/P molar ratio of the finally obtained precipitates increased to reach the stoichiometric value of 1.67. Acicular HAp nanocrystals grew from the inter-particle phase between the spherical particles within the ACP aggregates in an initial stage of the phase transformation. This observation is in favour of the view that the internal rearrangement process is responsible for the ACP-HAp transformation - it is against the opinion suggesting a dissolution-reprecipitation process.

Original language	English
Pages (from-to)	500-506
Number of pages	7
Journal	Materials Chemistry and Physics
Volume	91
Issue number	2-3
DOIs	https://doi.org/10.1016/j.matchemphys.2004.12.016
State	Published - 15 Jun 2005
Externally published	Yes

Keywords

Biomaterials
Crystallisation
Nucleation
Precipitation

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10.1016/j.matchemphys.2004.12.016

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title = "In situ observation of hydroxyapatite nanocrystal formation from amorphous calcium phosphate in calcium-rich solutions",

abstract = "The formation of hydroxyapatite (HAp) from amorphous calcium phosphate (ACP) was in situ observed in calcium-rich aqueous solutions (Ca/P molar ratios were 1.67, 1.83, and 2.0) by freeze-drying the precipitates withdrawn at selected time intervals during the reaction. As the more excess calcium ions exist in the solution, the HAp crystallization from ACP occurred more rapidly and the Ca/P molar ratio of the finally obtained precipitates increased to reach the stoichiometric value of 1.67. Acicular HAp nanocrystals grew from the inter-particle phase between the spherical particles within the ACP aggregates in an initial stage of the phase transformation. This observation is in favour of the view that the internal rearrangement process is responsible for the ACP-HAp transformation - it is against the opinion suggesting a dissolution-reprecipitation process.",

keywords = "Biomaterials, Crystallisation, Nucleation, Precipitation",

author = "Sujin Kim and Ryu, \{Hyun Seung\} and Hyunho Shin and Jung, \{Hyun Suk\} and Hong, \{Kug Sun\}",

year = "2005",

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doi = "10.1016/j.matchemphys.2004.12.016",

language = "English",

volume = "91",

pages = "500--506",

journal = "Materials Chemistry and Physics",

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TY - JOUR

T1 - In situ observation of hydroxyapatite nanocrystal formation from amorphous calcium phosphate in calcium-rich solutions

AU - Kim, Sujin

AU - Ryu, Hyun Seung

AU - Shin, Hyunho

AU - Jung, Hyun Suk

AU - Hong, Kug Sun

PY - 2005/6/15

Y1 - 2005/6/15

N2 - The formation of hydroxyapatite (HAp) from amorphous calcium phosphate (ACP) was in situ observed in calcium-rich aqueous solutions (Ca/P molar ratios were 1.67, 1.83, and 2.0) by freeze-drying the precipitates withdrawn at selected time intervals during the reaction. As the more excess calcium ions exist in the solution, the HAp crystallization from ACP occurred more rapidly and the Ca/P molar ratio of the finally obtained precipitates increased to reach the stoichiometric value of 1.67. Acicular HAp nanocrystals grew from the inter-particle phase between the spherical particles within the ACP aggregates in an initial stage of the phase transformation. This observation is in favour of the view that the internal rearrangement process is responsible for the ACP-HAp transformation - it is against the opinion suggesting a dissolution-reprecipitation process.

AB - The formation of hydroxyapatite (HAp) from amorphous calcium phosphate (ACP) was in situ observed in calcium-rich aqueous solutions (Ca/P molar ratios were 1.67, 1.83, and 2.0) by freeze-drying the precipitates withdrawn at selected time intervals during the reaction. As the more excess calcium ions exist in the solution, the HAp crystallization from ACP occurred more rapidly and the Ca/P molar ratio of the finally obtained precipitates increased to reach the stoichiometric value of 1.67. Acicular HAp nanocrystals grew from the inter-particle phase between the spherical particles within the ACP aggregates in an initial stage of the phase transformation. This observation is in favour of the view that the internal rearrangement process is responsible for the ACP-HAp transformation - it is against the opinion suggesting a dissolution-reprecipitation process.

KW - Biomaterials

KW - Crystallisation

KW - Nucleation

KW - Precipitation

UR - https://www.scopus.com/pages/publications/15344344949

U2 - 10.1016/j.matchemphys.2004.12.016

DO - 10.1016/j.matchemphys.2004.12.016

M3 - Article

AN - SCOPUS:15344344949

SN - 0254-0584

VL - 91

SP - 500

EP - 506

JO - Materials Chemistry and Physics

JF - Materials Chemistry and Physics

IS - 2-3

ER -

In situ observation of hydroxyapatite nanocrystal formation from amorphous calcium phosphate in calcium-rich solutions

Abstract

Keywords

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