Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells

Wooram Park; Andrew C. Gordon; Soojeong Cho; Xiaoke Huang; Kathleen R. Harris; Andrew C. Larson; Dong Hyun Kim

doi:10.1021/acsami.7b02258

Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells

Wooram Park
, Andrew C. Gordon
, Soojeong Cho
, Xiaoke Huang
, Kathleen R. Harris
, Andrew C. Larson
, Dong Hyun Kim

Northwestern University

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T₂ contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition of IMM-MS significantly increased NK-cell infiltration into the liver tumor site.

Original language	English
Pages (from-to)	13819-13824
Number of pages	6
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	16
DOIs	https://doi.org/10.1021/acsami.7b02258
State	Published - 26 Apr 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

and image-guided therapy
cancer immunotherapy
interferon-gamma (IFN-γ)
microspheres
natural killer (NK) cells infiltration

Access to Document

10.1021/acsami.7b02258

Cite this

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title = "Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells",

abstract = "The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T2 contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition of IMM-MS significantly increased NK-cell infiltration into the liver tumor site.",

keywords = "and image-guided therapy, cancer immunotherapy, interferon-gamma (IFN-γ), microspheres, natural killer (NK) cells infiltration",

author = "Wooram Park and Gordon, \{Andrew C.\} and Soojeong Cho and Xiaoke Huang and Harris, \{Kathleen R.\} and Larson, \{Andrew C.\} and Kim, \{Dong Hyun\}",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

month = apr,

day = "26",

doi = "10.1021/acsami.7b02258",

language = "English",

volume = "9",

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journal = "ACS Applied Materials and Interfaces",

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TY - JOUR

T1 - Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells

AU - Park, Wooram

AU - Gordon, Andrew C.

AU - Cho, Soojeong

AU - Huang, Xiaoke

AU - Harris, Kathleen R.

AU - Larson, Andrew C.

AU - Kim, Dong Hyun

PY - 2017/4/26

Y1 - 2017/4/26

N2 - The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T2 contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition of IMM-MS significantly increased NK-cell infiltration into the liver tumor site.

AB - The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T2 contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition of IMM-MS significantly increased NK-cell infiltration into the liver tumor site.

KW - and image-guided therapy

KW - cancer immunotherapy

KW - interferon-gamma (IFN-γ)

KW - microspheres

KW - natural killer (NK) cells infiltration

UR - https://www.scopus.com/pages/publications/85018821793

U2 - 10.1021/acsami.7b02258

DO - 10.1021/acsami.7b02258

M3 - Article

C2 - 28406012

AN - SCOPUS:85018821793

SN - 1944-8244

VL - 9

SP - 13819

EP - 13824

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 16

ER -

Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells

Abstract

UN SDGs

Keywords

Access to Document

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