Identification of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as inhibitors of peroxisome-proliferator-activated receptor γ expression and lipid accumulation

Woo Seok Jang; No Joon Song; Hyang Jin Yoon; Min Ji Kim; Jin Mo Ku; Joung Woo Hong; Young Min Lee; Ki Moon Park; Kye Won Park

doi:10.1007/s13765-012-2039-z

Identification of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as inhibitors of peroxisome-proliferator-activated receptor γ expression and lipid accumulation

Woo Seok Jang, No Joon Song, Hyang Jin Yoon, Min Ji Kim, Jin Mo Ku, Joung Woo Hong, Young Min Lee, Ki Moon Park, Kye Won Park

Department of Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Screening of wild vegetable extracts led to isolation of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as putative anti-adipogenic herbal extracts. Cell viability, lipid accumulation, and adipocyte marker expression were determined to validate the effects of the selected extracts on adipogenesis. All extracts suppressed lipid accumulation in C3H10T1/2 cells, primary mouse embryonic fibroblasts, and 3T3-L1 cells in a dose-dependent manner. These extracts inhibited mRNA expression of peroxisome proliferator-activated receptor gamma (PPAR_γ) and its downstream target genes such as adipocyte protein 2 (aP2), lipoprotein lipase, adiponectin, and CD36. Treatment with these extracts also consistently suppressed PPAR_γ and aP2 protein expressions. Additionally, these extracts generated from different parts and/or various harvest periods similarly inhibited adipocyte differentiation. Results showed the extracts have potential beneficial roles in obesity and related metabolic syndromes.

Original language	English
Pages (from-to)	625-631
Number of pages	7
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume	55
Issue number	5
DOIs	https://doi.org/10.1007/s13765-012-2039-z
State	Published - Oct 2012

Keywords

adipocyte differentiation
natural products
obesity
peroxisome proliferator-activated receptor gamma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13765-012-2039-z

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Jang, W. S., Song, N. J., Yoon, H. J., Kim, M. J., Ku, J. M., Hong, J. W., Lee, Y. M., Park, K. M., & Park, K. W. (2012). Identification of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as inhibitors of peroxisome-proliferator-activated receptor γ expression and lipid accumulation. Journal of the Korean Society for Applied Biological Chemistry, 55(5), 625-631. https://doi.org/10.1007/s13765-012-2039-z

@article{5ecc517de49741d6872a4bf8b7c865be,

title = "Identification of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as inhibitors of peroxisome-proliferator-activated receptor γ expression and lipid accumulation",

abstract = "Screening of wild vegetable extracts led to isolation of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as putative anti-adipogenic herbal extracts. Cell viability, lipid accumulation, and adipocyte marker expression were determined to validate the effects of the selected extracts on adipogenesis. All extracts suppressed lipid accumulation in C3H10T1/2 cells, primary mouse embryonic fibroblasts, and 3T3-L1 cells in a dose-dependent manner. These extracts inhibited mRNA expression of peroxisome proliferator-activated receptor gamma (PPARγ) and its downstream target genes such as adipocyte protein 2 (aP2), lipoprotein lipase, adiponectin, and CD36. Treatment with these extracts also consistently suppressed PPARγ and aP2 protein expressions. Additionally, these extracts generated from different parts and/or various harvest periods similarly inhibited adipocyte differentiation. Results showed the extracts have potential beneficial roles in obesity and related metabolic syndromes.",

keywords = "adipocyte differentiation, natural products, obesity, peroxisome proliferator-activated receptor gamma",

author = "Jang, \{Woo Seok\} and Song, \{No Joon\} and Yoon, \{Hyang Jin\} and Kim, \{Min Ji\} and Ku, \{Jin Mo\} and Hong, \{Joung Woo\} and Lee, \{Young Min\} and Park, \{Ki Moon\} and Park, \{Kye Won\}",

year = "2012",

month = oct,

doi = "10.1007/s13765-012-2039-z",

language = "English",

volume = "55",

pages = "625--631",

journal = "Journal of the Korean Society for Applied Biological Chemistry",

issn = "1738-2203",

publisher = "The Korean Society for Applied Biological Chemistry",

number = "5",

}

Jang, WS, Song, NJ, Yoon, HJ, Kim, MJ, Ku, JM, Hong, JW, Lee, YM, Park, KM & Park, KW 2012, 'Identification of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as inhibitors of peroxisome-proliferator-activated receptor γ expression and lipid accumulation', Journal of the Korean Society for Applied Biological Chemistry, vol. 55, no. 5, pp. 625-631. https://doi.org/10.1007/s13765-012-2039-z

Identification of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as inhibitors of peroxisome-proliferator-activated receptor γ expression and lipid accumulation. / Jang, Woo Seok; Song, No Joon; Yoon, Hyang Jin et al.
In: Journal of the Korean Society for Applied Biological Chemistry, Vol. 55, No. 5, 10.2012, p. 625-631.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Identification of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as inhibitors of peroxisome-proliferator-activated receptor γ expression and lipid accumulation

AU - Jang, Woo Seok

AU - Song, No Joon

AU - Yoon, Hyang Jin

AU - Kim, Min Ji

AU - Ku, Jin Mo

AU - Hong, Joung Woo

AU - Lee, Young Min

AU - Park, Ki Moon

AU - Park, Kye Won

PY - 2012/10

Y1 - 2012/10

N2 - Screening of wild vegetable extracts led to isolation of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as putative anti-adipogenic herbal extracts. Cell viability, lipid accumulation, and adipocyte marker expression were determined to validate the effects of the selected extracts on adipogenesis. All extracts suppressed lipid accumulation in C3H10T1/2 cells, primary mouse embryonic fibroblasts, and 3T3-L1 cells in a dose-dependent manner. These extracts inhibited mRNA expression of peroxisome proliferator-activated receptor gamma (PPARγ) and its downstream target genes such as adipocyte protein 2 (aP2), lipoprotein lipase, adiponectin, and CD36. Treatment with these extracts also consistently suppressed PPARγ and aP2 protein expressions. Additionally, these extracts generated from different parts and/or various harvest periods similarly inhibited adipocyte differentiation. Results showed the extracts have potential beneficial roles in obesity and related metabolic syndromes.

AB - Screening of wild vegetable extracts led to isolation of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as putative anti-adipogenic herbal extracts. Cell viability, lipid accumulation, and adipocyte marker expression were determined to validate the effects of the selected extracts on adipogenesis. All extracts suppressed lipid accumulation in C3H10T1/2 cells, primary mouse embryonic fibroblasts, and 3T3-L1 cells in a dose-dependent manner. These extracts inhibited mRNA expression of peroxisome proliferator-activated receptor gamma (PPARγ) and its downstream target genes such as adipocyte protein 2 (aP2), lipoprotein lipase, adiponectin, and CD36. Treatment with these extracts also consistently suppressed PPARγ and aP2 protein expressions. Additionally, these extracts generated from different parts and/or various harvest periods similarly inhibited adipocyte differentiation. Results showed the extracts have potential beneficial roles in obesity and related metabolic syndromes.

KW - adipocyte differentiation

KW - natural products

KW - obesity

KW - peroxisome proliferator-activated receptor gamma

UR - https://www.scopus.com/pages/publications/84868307056

U2 - 10.1007/s13765-012-2039-z

DO - 10.1007/s13765-012-2039-z

M3 - Article

AN - SCOPUS:84868307056

SN - 1738-2203

VL - 55

SP - 625

EP - 631

JO - Journal of the Korean Society for Applied Biological Chemistry

JF - Journal of the Korean Society for Applied Biological Chemistry

IS - 5

ER -

Identification of Sedum kamtschaticum, Lythrum anceps, and Astilbe chinensis var. davidii as inhibitors of peroxisome-proliferator-activated receptor γ expression and lipid accumulation

Abstract

Keywords

UN SDGs

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