Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family

Donggyu Jo; Myuhg Soo Lyu; Eun Gyung Cho; Dongeun Park; Christine A. Kozak; Moon Gyo Kim

doi:10.1016/s1016-8478(23)17096-8

Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family

Donggyu Jo
, Myuhg Soo Lyu
, Eun Gyung Cho
, Dongeun Park
, Christine A. Kozak
, Moon Gyo Kim

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We have isolated a gene from a cDNA library generated from the thymus of a mouse with severe combined immune deficiency, termed FKBP9, that encodes a protein related to FK506-binding protein 6 (65 kDa, FKBP65). FKBP9 contains four peptidyl-prolyl cis-trans isomerase (PPIase) signature and two EF-hand domains which is identical to FKBP6/65 in overall structural organization. However, the two proteins share only 66% amino acid identity. FKBP9 is expressed at high levels in mouse heart, muscle, lung, and kidney. While FKBP6 was previously mapped to chromosome 11, the Fkbp9 gene was mapped to mouse chromosome 6 by analysis of a multilocus cross. These results identify a new member of the mouse FKBP protein family located on a separate chromosome.

Original language	English
Pages (from-to)	272-275
Number of pages	4
Journal	Molecules and Cells
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/s1016-8478(23)17096-8
State	Published - 31 Oct 2001
Externally published	Yes

Keywords

FKBP
Genetic Mapping

Access to Document

10.1016/s1016-8478(23)17096-8

Cite this

@article{0ddfbe2ddb9b4ddaa7d803ad4679e13b,

title = "Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family",

abstract = "We have isolated a gene from a cDNA library generated from the thymus of a mouse with severe combined immune deficiency, termed FKBP9, that encodes a protein related to FK506-binding protein 6 (65 kDa, FKBP65). FKBP9 contains four peptidyl-prolyl cis-trans isomerase (PPIase) signature and two EF-hand domains which is identical to FKBP6/65 in overall structural organization. However, the two proteins share only 66\% amino acid identity. FKBP9 is expressed at high levels in mouse heart, muscle, lung, and kidney. While FKBP6 was previously mapped to chromosome 11, the Fkbp9 gene was mapped to mouse chromosome 6 by analysis of a multilocus cross. These results identify a new member of the mouse FKBP protein family located on a separate chromosome.",

keywords = "FKBP, Genetic Mapping",

author = "Donggyu Jo and Lyu, \{Myuhg Soo\} and Cho, \{Eun Gyung\} and Dongeun Park and Kozak, \{Christine A.\} and Kim, \{Moon Gyo\}",

year = "2001",

month = oct,

day = "31",

doi = "10.1016/s1016-8478(23)17096-8",

language = "English",

volume = "12",

pages = "272--275",

journal = "Molecules and Cells",

issn = "1016-8478",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family

AU - Jo, Donggyu

AU - Lyu, Myuhg Soo

AU - Cho, Eun Gyung

AU - Park, Dongeun

AU - Kozak, Christine A.

AU - Kim, Moon Gyo

PY - 2001/10/31

Y1 - 2001/10/31

N2 - We have isolated a gene from a cDNA library generated from the thymus of a mouse with severe combined immune deficiency, termed FKBP9, that encodes a protein related to FK506-binding protein 6 (65 kDa, FKBP65). FKBP9 contains four peptidyl-prolyl cis-trans isomerase (PPIase) signature and two EF-hand domains which is identical to FKBP6/65 in overall structural organization. However, the two proteins share only 66% amino acid identity. FKBP9 is expressed at high levels in mouse heart, muscle, lung, and kidney. While FKBP6 was previously mapped to chromosome 11, the Fkbp9 gene was mapped to mouse chromosome 6 by analysis of a multilocus cross. These results identify a new member of the mouse FKBP protein family located on a separate chromosome.

AB - We have isolated a gene from a cDNA library generated from the thymus of a mouse with severe combined immune deficiency, termed FKBP9, that encodes a protein related to FK506-binding protein 6 (65 kDa, FKBP65). FKBP9 contains four peptidyl-prolyl cis-trans isomerase (PPIase) signature and two EF-hand domains which is identical to FKBP6/65 in overall structural organization. However, the two proteins share only 66% amino acid identity. FKBP9 is expressed at high levels in mouse heart, muscle, lung, and kidney. While FKBP6 was previously mapped to chromosome 11, the Fkbp9 gene was mapped to mouse chromosome 6 by analysis of a multilocus cross. These results identify a new member of the mouse FKBP protein family located on a separate chromosome.

KW - FKBP

KW - Genetic Mapping

UR - https://www.scopus.com/pages/publications/0035980771

U2 - 10.1016/s1016-8478(23)17096-8

DO - 10.1016/s1016-8478(23)17096-8

M3 - Article

C2 - 11710534

AN - SCOPUS:0035980771

SN - 1016-8478

VL - 12

SP - 272

EP - 275

JO - Molecules and Cells

JF - Molecules and Cells

IS - 2

ER -

Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this