Hyaluronic acid-based nanocarriers for intracellular targeting: Interfacial interactions with proteins in cancer

Ki Young Choi; Gurusamy Saravanakumar; Jae Hyung Park; Kinam Park

doi:10.1016/j.colsurfb.2011.10.029

Hyaluronic acid-based nanocarriers for intracellular targeting: Interfacial interactions with proteins in cancer

Ki Young Choi
, Gurusamy Saravanakumar
, Jae Hyung Park
, Kinam Park

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

254 Scopus citations

Abstract

The therapeutic efficacy of most drugs is greatly depends on their ability to cross the cellular barrier and reach their intracellular target sites. To transport the drugs effectively through the cellular membrane and to deliver them into the intracellular environment, several interesting smart carrier systems based on both synthetic or natural polymers have been designed and developed. In recent years, hyaluronic acid (HA) has emerged as a promising candidate for intracellular delivery of various therapeutic and imaging agents because of its innate ability to recognize specific cellular receptors that overexpressed on diseased cells. The aim of this review is to highlight the significance of HA in cancer, and to explore the recent advances of HA-based drug carriers towards cancer imaging and therapeutics.

Original language	English
Pages (from-to)	82-94
Number of pages	13
Journal	Colloids and Surfaces B: Biointerfaces
Volume	99
DOIs	https://doi.org/10.1016/j.colsurfb.2011.10.029
State	Published - 1 Nov 2012

Keywords

Drug delivery
Hyaluronic acid
Intracellular targeting
Nanocarrier
Tumor imaging
Tumor targeting

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.colsurfb.2011.10.029

Cite this

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title = "Hyaluronic acid-based nanocarriers for intracellular targeting: Interfacial interactions with proteins in cancer",

abstract = "The therapeutic efficacy of most drugs is greatly depends on their ability to cross the cellular barrier and reach their intracellular target sites. To transport the drugs effectively through the cellular membrane and to deliver them into the intracellular environment, several interesting smart carrier systems based on both synthetic or natural polymers have been designed and developed. In recent years, hyaluronic acid (HA) has emerged as a promising candidate for intracellular delivery of various therapeutic and imaging agents because of its innate ability to recognize specific cellular receptors that overexpressed on diseased cells. The aim of this review is to highlight the significance of HA in cancer, and to explore the recent advances of HA-based drug carriers towards cancer imaging and therapeutics.",

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AU - Saravanakumar, Gurusamy

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AU - Park, Kinam

PY - 2012/11/1

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N2 - The therapeutic efficacy of most drugs is greatly depends on their ability to cross the cellular barrier and reach their intracellular target sites. To transport the drugs effectively through the cellular membrane and to deliver them into the intracellular environment, several interesting smart carrier systems based on both synthetic or natural polymers have been designed and developed. In recent years, hyaluronic acid (HA) has emerged as a promising candidate for intracellular delivery of various therapeutic and imaging agents because of its innate ability to recognize specific cellular receptors that overexpressed on diseased cells. The aim of this review is to highlight the significance of HA in cancer, and to explore the recent advances of HA-based drug carriers towards cancer imaging and therapeutics.

AB - The therapeutic efficacy of most drugs is greatly depends on their ability to cross the cellular barrier and reach their intracellular target sites. To transport the drugs effectively through the cellular membrane and to deliver them into the intracellular environment, several interesting smart carrier systems based on both synthetic or natural polymers have been designed and developed. In recent years, hyaluronic acid (HA) has emerged as a promising candidate for intracellular delivery of various therapeutic and imaging agents because of its innate ability to recognize specific cellular receptors that overexpressed on diseased cells. The aim of this review is to highlight the significance of HA in cancer, and to explore the recent advances of HA-based drug carriers towards cancer imaging and therapeutics.

KW - Drug delivery

KW - Hyaluronic acid

KW - Intracellular targeting

KW - Nanocarrier

KW - Tumor imaging

KW - Tumor targeting

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JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

ER -

Hyaluronic acid-based nanocarriers for intracellular targeting: Interfacial interactions with proteins in cancer

Abstract

Keywords

UN SDGs

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