Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla

Chung Sub Kim; Bora Shin; Oh Wook Kwon; Sun Yeou Kim; Sang Un Choi; Dong Chan Oh; Ki Hyun Kim; Kang Ro Lee

doi:10.1016/j.tetlet.2014.10.030

Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla

Chung Sub Kim, Bora Shin, Oh Wook Kwon, Sun Yeou Kim, Sang Un Choi, Dong Chan Oh, Ki Hyun Kim, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.

Original language	English
Pages (from-to)	6504-6507
Number of pages	4
Journal	Tetrahedron Letters
Volume	55
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2014.10.030
State	Published - 19 Nov 2014

Keywords

Abies holophylla
Abietane diterpene
Pinaceae
Spiro compound

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10.1016/j.tetlet.2014.10.030

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title = "Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla",

abstract = "Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.",

keywords = "Abies holophylla, Abietane diterpene, Pinaceae, Spiro compound",

author = "Kim, \{Chung Sub\} and Bora Shin and Kwon, \{Oh Wook\} and Kim, \{Sun Yeou\} and Choi, \{Sang Un\} and Oh, \{Dong Chan\} and Kim, \{Ki Hyun\} and Lee, \{Kang Ro\}",

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T1 - Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla

AU - Kim, Chung Sub

AU - Shin, Bora

AU - Kwon, Oh Wook

AU - Kim, Sun Yeou

AU - Choi, Sang Un

AU - Oh, Dong Chan

AU - Kim, Ki Hyun

AU - Lee, Kang Ro

PY - 2014/11/19

Y1 - 2014/11/19

N2 - Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.

AB - Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.

KW - Abies holophylla

KW - Abietane diterpene

KW - Pinaceae

KW - Spiro compound

UR - https://www.scopus.com/pages/publications/84908324840

U2 - 10.1016/j.tetlet.2014.10.030

DO - 10.1016/j.tetlet.2014.10.030

M3 - Article

AN - SCOPUS:84908324840

SN - 0040-4039

VL - 55

SP - 6504

EP - 6507

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 47

ER -

Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla

Abstract

Keywords

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