Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla

Chung Sub Kim; Bora Shin; Oh Wook Kwon; Sun Yeou Kim; Sang Un Choi; Dong Chan Oh; Ki Hyun Kim; Kang Ro Lee

doi:10.1016/j.tetlet.2014.10.030

Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla

Chung Sub Kim
, Bora Shin
, Oh Wook Kwon
, Sun Yeou Kim
, Sang Un Choi
, Dong Chan Oh
, Ki Hyun Kim
, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.

Original language	English
Pages (from-to)	6504-6507
Number of pages	4
Journal	Tetrahedron Letters
Volume	55
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2014.10.030
State	Published - 19 Nov 2014

Keywords

Abies holophylla
Abietane diterpene
Pinaceae
Spiro compound

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10.1016/j.tetlet.2014.10.030

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title = "Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla",

abstract = "Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.",

keywords = "Abies holophylla, Abietane diterpene, Pinaceae, Spiro compound",

author = "Kim, \{Chung Sub\} and Bora Shin and Kwon, \{Oh Wook\} and Kim, \{Sun Yeou\} and Choi, \{Sang Un\} and Oh, \{Dong Chan\} and Kim, \{Ki Hyun\} and Lee, \{Kang Ro\}",

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T1 - Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla

AU - Kim, Chung Sub

AU - Shin, Bora

AU - Kwon, Oh Wook

AU - Kim, Sun Yeou

AU - Choi, Sang Un

AU - Oh, Dong Chan

AU - Kim, Ki Hyun

AU - Lee, Kang Ro

PY - 2014/11/19

Y1 - 2014/11/19

N2 - Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.

AB - Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.

KW - Abies holophylla

KW - Abietane diterpene

KW - Pinaceae

KW - Spiro compound

UR - https://www.scopus.com/pages/publications/84908324840

U2 - 10.1016/j.tetlet.2014.10.030

DO - 10.1016/j.tetlet.2014.10.030

M3 - Article

AN - SCOPUS:84908324840

SN - 0040-4039

VL - 55

SP - 6504

EP - 6507

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 47

ER -

Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla

Abstract

Keywords

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