Hippocampal volume and shape in pure subcortical vascular dementia

Geon Ha Kim; Jae Hong Lee; Sang Won Seo; Jeong Hun Kim; Joon Kyung Seong; Byoung Seok Ye; Hanna Cho; Young Noh; Hee Jin Kim; Cindy W. Yoon; Seung Jun Oh; Jae Seung Kim; Yearn Seong Choe; Kyung Han Lee; Sung Tae Kim; Jung Won Hwang; Jee Hyang Jeong; Duk L. Na

doi:10.1016/j.neurobiolaging.2014.08.009

Hippocampal volume and shape in pure subcortical vascular dementia

Geon Ha Kim
, Jae Hong Lee
, Sang Won Seo
, Jeong Hun Kim
, Joon Kyung Seong
, Byoung Seok Ye
, Hanna Cho
, Young Noh
, Hee Jin Kim
, Cindy W. Yoon
, Seung Jun Oh
, Jae Seung Kim
, Yearn Seong Choe
, Kyung Han Lee
, Sung Tae Kim
, Jung Won Hwang
, Jee Hyang Jeong
, Duk L. Na

Department of Radiology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative ¹¹C-Pittsburg compound-B (PiB^-) positron emission tomography and to compare hippocampal volume and shape between PiB^- SVaD and PiB positive (PiB⁺) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB^- SVaD, 34 with PiB⁺ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB^- SVaD was significantly smaller than NC but larger than that of PiB⁺ AD (NC > PiB^- SVaD > PiB⁺ AD). Both PiB^- SVaD and PiB⁺ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB^- SVaD and PiB⁺ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB⁺ AD. PiB^- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

Original language	English
Pages (from-to)	485-491
Number of pages	7
Journal	Neurobiology of Aging
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.08.009
State	Published - 1 Jan 2015

Keywords

Alzheimer's disease
Hippocampus
PiB-PET
Vascular dementia

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10.1016/j.neurobiolaging.2014.08.009

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Kim, G. H., Lee, J. H., Seo, S. W., Kim, J. H., Seong, J. K., Ye, B. S., Cho, H., Noh, Y., Kim, H. J., Yoon, C. W., Oh, S. J., Kim, J. S., Choe, Y. S., Lee, K. H., Kim, S. T., Hwang, J. W., Jeong, J. H., & Na, D. L. (2015). Hippocampal volume and shape in pure subcortical vascular dementia. Neurobiology of Aging, 36(1), 485-491. https://doi.org/10.1016/j.neurobiolaging.2014.08.009

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title = "Hippocampal volume and shape in pure subcortical vascular dementia",

abstract = "The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.",

keywords = "Alzheimer's disease, Hippocampus, PiB-PET, Vascular dementia",

author = "Kim, \{Geon Ha\} and Lee, \{Jae Hong\} and Seo, \{Sang Won\} and Kim, \{Jeong Hun\} and Seong, \{Joon Kyung\} and Ye, \{Byoung Seok\} and Hanna Cho and Young Noh and Kim, \{Hee Jin\} and Yoon, \{Cindy W.\} and Oh, \{Seung Jun\} and Kim, \{Jae Seung\} and Choe, \{Yearn Seong\} and Lee, \{Kyung Han\} and Kim, \{Sung Tae\} and Hwang, \{Jung Won\} and Jeong, \{Jee Hyang\} and Na, \{Duk L.\}",

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AU - Lee, Jae Hong

AU - Seo, Sang Won

AU - Kim, Jeong Hun

AU - Seong, Joon Kyung

AU - Ye, Byoung Seok

AU - Cho, Hanna

AU - Noh, Young

AU - Kim, Hee Jin

AU - Yoon, Cindy W.

AU - Oh, Seung Jun

AU - Kim, Jae Seung

AU - Choe, Yearn Seong

AU - Lee, Kyung Han

AU - Kim, Sung Tae

AU - Hwang, Jung Won

AU - Jeong, Jee Hyang

AU - Na, Duk L.

PY - 2015/1/1

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N2 - The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

AB - The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

KW - Alzheimer's disease

KW - Hippocampus

KW - PiB-PET

KW - Vascular dementia

UR - https://www.scopus.com/pages/publications/84920382033

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SN - 0197-4580

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SP - 485

EP - 491

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 1

ER -

Hippocampal volume and shape in pure subcortical vascular dementia

Abstract

Keywords

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