High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea

Cheol Park Su; Sook Hyang Jeong; Jin Kim; Ju Han Chul; Cheoul Kim You; Sung Choi Kui; Hyun Cho Jang; Myoungjin Lee; Hyun Jung Ha; Seog Ki Seung; Hwan Chang Yoon; Sook Lee Seung; Hee Park Yeon; Ho Lee Kee

doi:10.1002/jmv.21168

High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea

Cheol Park Su
, Sook Hyang Jeong
, Jin Kim
, Ju Han Chul
, Cheoul Kim You
, Sung Choi Kui
, Hyun Cho Jang
, Myoungjin Lee
, Hyun Jung Ha
, Seog Ki Seung
, Hwan Chang Yoon
, Sook Lee Seung
, Hee Park Yeon
, Ho Lee Kee

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible rolefor HBV in the development of non-Hodgkin's lymphoma.

Original language	English
Pages (from-to)	960-966
Number of pages	7
Journal	Journal of Medical Virology
Volume	80
Issue number	6
DOIs	https://doi.org/10.1002/jmv.21168
State	Published - Jun 2008
Externally published	Yes

Keywords

B-cell lymphoma
Hepatitis B virus
Human
non-Hodgkin's lymphoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.21168

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@article{d10265ad2ea24005b5ffa6c25e17c224,

title = "High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea",

abstract = "This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5\%) than control (8.1\%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1\%) and control group (3\%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible rolefor HBV in the development of non-Hodgkin's lymphoma.",

keywords = "B-cell lymphoma, Hepatitis B virus, Human, non-Hodgkin's lymphoma",

author = "Su, \{Cheol Park\} and Jeong, \{Sook Hyang\} and Jin Kim and Chul, \{Ju Han\} and You, \{Cheoul Kim\} and Kui, \{Sung Choi\} and Jang, \{Hyun Cho\} and Myoungjin Lee and Ha, \{Hyun Jung\} and Seung, \{Seog Ki\} and Yoon, \{Hwan Chang\} and Seung, \{Sook Lee\} and Yeon, \{Hee Park\} and Kee, \{Ho Lee\}",

year = "2008",

month = jun,

doi = "10.1002/jmv.21168",

language = "English",

volume = "80",

pages = "960--966",

journal = "Journal of Medical Virology",

issn = "0146-6615",

publisher = "John Wiley and Sons Inc",

number = "6",

}

TY - JOUR

T1 - High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea

AU - Su, Cheol Park

AU - Jeong, Sook Hyang

AU - Kim, Jin

AU - Chul, Ju Han

AU - You, Cheoul Kim

AU - Kui, Sung Choi

AU - Jang, Hyun Cho

AU - Lee, Myoungjin

AU - Ha, Hyun Jung

AU - Seung, Seog Ki

AU - Yoon, Hwan Chang

AU - Seung, Sook Lee

AU - Yeon, Hee Park

AU - Kee, Ho Lee

PY - 2008/6

Y1 - 2008/6

N2 - This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible rolefor HBV in the development of non-Hodgkin's lymphoma.

AB - This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible rolefor HBV in the development of non-Hodgkin's lymphoma.

KW - B-cell lymphoma

KW - Hepatitis B virus

KW - Human

KW - non-Hodgkin's lymphoma

UR - https://www.scopus.com/pages/publications/43249109672

U2 - 10.1002/jmv.21168

DO - 10.1002/jmv.21168

M3 - Article

C2 - 18428141

AN - SCOPUS:43249109672

SN - 0146-6615

VL - 80

SP - 960

EP - 966

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 6

ER -

High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea

Abstract

Keywords

UN SDGs

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