Abstract
Many studies have shown the effectiveness of platelet-rich plasma on various wound healing. Little is known about grafted cartilage healing with platelet-rich plasma. In this study the healing effect of platelet-rich plasma for grafted cartilage in rabbit were studied. Six New-zealand white rabbit were used. Total 48 pieces of ear cartilage were harvested from rabbit ear using a 6 mm biopsy punch. Each cartilage was grafted on their own harvested site. Grafted cartilages were divided two groups. Group A was control, Group B was applied platelet-rich plasma treatment for 7 days. Specimens were subsequently harvested 2, 4, 8 weeks after grafting. In Histologic examination, Group B was noted more increased, newly formed cartilage than Group A at each period. The number of PCNA-labeled cells was significantly increased in Group B than Group A. Mean number of PCNA-labeled cells in Group A and Group B were 125.13 ± 9.3 cells/HPF and 165.38 ± 43.2 cells/HPF, respectively(p<0.05). Our results suggest that Platelet-rich plasma to enhance healing process of grafted ear cartilage in rabbit.
| Original language | English |
|---|---|
| Pages (from-to) | 629-635 |
| Number of pages | 7 |
| Journal | Tissue Engineering and Regenerative Medicine |
| Volume | 6 |
| Issue number | 4-11 |
| State | Published - Jun 2009 |
| Externally published | Yes |
Keywords
- Cartilage
- Cartilage graft
- Platelet-rich plasma
- Wound healing