Gold-installed biostable nanocomplexes for tumor-targeted siRNA delivery in vivo

Roun Heo, Hong Yeol Yoon, Hyewon Ko, Jung Min Shin, Jueun Jeon, Yee Soo Chae, Young Mo Kang, Dukjoon Kim, Doo Sung Lee, Jae Hyung Park

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these issues, we developed gold-installed polyethyleneimine/siRNA complexes with a corona of PEGylated hyaluronic acid.

Original languageEnglish
Pages (from-to)16656-16659
Number of pages4
JournalChemical Communications
Volume51
Issue number93
DOIs
StatePublished - 2015

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