Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer

Ho Jun Seol; Juyoun Jin; Dong Ho Seong; Kyeung Min Joo; Wonyoung Kang; Heekyoung Yang; Jandi Kim; Chul Soo Shin; Yonghyun Kim; Kang Ho Kim; Doo Sik Kong; Jung I.I. Lee; Karen S. Aboody; Hong Jun Lee; Seung U. Kim; Do Hyun Nam

doi:10.1016/j.canlet.2011.07.001

Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer

Ho Jun Seol
, Juyoun Jin
, Dong Ho Seong
, Kyeung Min Joo
, Wonyoung Kang
, Heekyoung Yang
, Jandi Kim
, Chul Soo Shin
, Yonghyun Kim
, Kang Ho Kim
, Doo Sik Kong
, Jung I.I. Lee
, Karen S. Aboody
, Hong Jun Lee
, Seung U. Kim
, Do Hyun Nam

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases.

Original language	English
Pages (from-to)	152-159
Number of pages	8
Journal	Cancer Letters
Volume	311
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2011.07.001
State	Published - 8 Dec 2011

Keywords

Carboxyl esterase (CE)
CPT-11
Metastatic brain tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2011.07.001

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Seol, H. J., Jin, J., Seong, D. H., Joo, K. M., Kang, W., Yang, H., Kim, J., Shin, C. S., Kim, Y., Kim, K. H., Kong, D. S., Lee, J. I. I., Aboody, K. S., Lee, H. J., Kim, S. U., & Nam, D. H. (2011). Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer. Cancer Letters, 311(2), 152-159. https://doi.org/10.1016/j.canlet.2011.07.001

@article{1c2ce5c123584fc8baff58b3ac097c0b,

title = "Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer",

abstract = "Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases.",

keywords = "Carboxyl esterase (CE), CPT-11, Metastatic brain tumor",

author = "Seol, \{Ho Jun\} and Juyoun Jin and Seong, \{Dong Ho\} and Joo, \{Kyeung Min\} and Wonyoung Kang and Heekyoung Yang and Jandi Kim and Shin, \{Chul Soo\} and Yonghyun Kim and Kim, \{Kang Ho\} and Kong, \{Doo Sik\} and Lee, \{Jung I.I.\} and Aboody, \{Karen S.\} and Lee, \{Hong Jun\} and Kim, \{Seung U.\} and Nam, \{Do Hyun\}",

year = "2011",

month = dec,

day = "8",

doi = "10.1016/j.canlet.2011.07.001",

language = "English",

volume = "311",

pages = "152--159",

journal = "Cancer Letters",

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publisher = "Elsevier Ireland Ltd",

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Seol, HJ, Jin, J, Seong, DH, Joo, KM, Kang, W, Yang, H, Kim, J, Shin, CS, Kim, Y, Kim, KH, Kong, DS , Lee, JII, Aboody, KS, Lee, HJ, Kim, SU & Nam, DH 2011, 'Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer', Cancer Letters, vol. 311, no. 2, pp. 152-159. https://doi.org/10.1016/j.canlet.2011.07.001

TY - JOUR

T1 - Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer

AU - Seol, Ho Jun

AU - Jin, Juyoun

AU - Seong, Dong Ho

AU - Joo, Kyeung Min

AU - Kang, Wonyoung

AU - Yang, Heekyoung

AU - Kim, Jandi

AU - Shin, Chul Soo

AU - Kim, Yonghyun

AU - Kim, Kang Ho

AU - Kong, Doo Sik

AU - Lee, Jung I.I.

AU - Aboody, Karen S.

AU - Lee, Hong Jun

AU - Kim, Seung U.

AU - Nam, Do Hyun

PY - 2011/12/8

Y1 - 2011/12/8

N2 - Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases.

AB - Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases.

KW - Carboxyl esterase (CE)

KW - CPT-11

KW - Metastatic brain tumor

UR - https://www.scopus.com/pages/publications/84860388865

U2 - 10.1016/j.canlet.2011.07.001

DO - 10.1016/j.canlet.2011.07.001

M3 - Article

C2 - 21868150

AN - SCOPUS:84860388865

SN - 0304-3835

VL - 311

SP - 152

EP - 159

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer

Abstract

Keywords

UN SDGs

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