Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

K. M. Lee; J. Abel; Y. Ko; V. Harth; W. Y. Park; J. S. Seo; K. Y. Yoo; J. Y. Choi; A. Shin; S. H. Ahn; D. Y. Noh; A. Hirvonen; D. Kang

doi:10.1038/sj.bjc.6600761

Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

K. M. Lee
, J. Abel
, Y. Ko
, V. Harth
, W. Y. Park
, J. S. Seo
, K. Y. Yoo
, J. Y. Choi
, A. Shin
, S. H. Ahn
, D. Y. Noh
, A. Hirvonen
, D. Kang

Seoul National University
Heinrich Heine University Düsseldorf
University of Bonn
University of Ulsan
Finnish Institute of Occupational Health

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

A case-control study was performed to assess the potential influence of CYP19 Arg²⁶⁴Cys and CYP1B1 Leu⁴³²Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg²⁶⁴Cys polymorphism modifies breast cancer risk (OR = 1.5, 95% CI = 1.1-2.2), especially in association with alcohol consumption (P for interaction = 0.04), whereas the CYP1B1 Leu⁴³²Val polymorphism appears to play no role here.

Original language	English
Pages (from-to)	675-678
Number of pages	4
Journal	British Journal of Cancer
Volume	88
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjc.6600761
State	Published - 10 Mar 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alcohol
Breast cancer
CYP19
CYP1B1

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10.1038/sj.bjc.6600761

Cite this

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title = "Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women",

abstract = "A case-control study was performed to assess the potential influence of CYP19 Arg264Cys and CYP1B1 Leu432Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg264Cys polymorphism modifies breast cancer risk (OR = 1.5, 95\% CI = 1.1-2.2), especially in association with alcohol consumption (P for interaction = 0.04), whereas the CYP1B1 Leu432Val polymorphism appears to play no role here.",

keywords = "Alcohol, Breast cancer, CYP19, CYP1B1",

author = "Lee, \{K. M.\} and J. Abel and Y. Ko and V. Harth and Park, \{W. Y.\} and Seo, \{J. S.\} and Yoo, \{K. Y.\} and Choi, \{J. Y.\} and A. Shin and Ahn, \{S. H.\} and Noh, \{D. Y.\} and A. Hirvonen and D. Kang",

year = "2003",

month = mar,

day = "10",

doi = "10.1038/sj.bjc.6600761",

language = "English",

volume = "88",

pages = "675--678",

journal = "British Journal of Cancer",

issn = "0007-0920",

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}

TY - JOUR

T1 - Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

AU - Lee, K. M.

AU - Abel, J.

AU - Ko, Y.

AU - Harth, V.

AU - Park, W. Y.

AU - Seo, J. S.

AU - Yoo, K. Y.

AU - Choi, J. Y.

AU - Shin, A.

AU - Ahn, S. H.

AU - Noh, D. Y.

AU - Hirvonen, A.

AU - Kang, D.

PY - 2003/3/10

Y1 - 2003/3/10

N2 - A case-control study was performed to assess the potential influence of CYP19 Arg264Cys and CYP1B1 Leu432Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg264Cys polymorphism modifies breast cancer risk (OR = 1.5, 95% CI = 1.1-2.2), especially in association with alcohol consumption (P for interaction = 0.04), whereas the CYP1B1 Leu432Val polymorphism appears to play no role here.

AB - A case-control study was performed to assess the potential influence of CYP19 Arg264Cys and CYP1B1 Leu432Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg264Cys polymorphism modifies breast cancer risk (OR = 1.5, 95% CI = 1.1-2.2), especially in association with alcohol consumption (P for interaction = 0.04), whereas the CYP1B1 Leu432Val polymorphism appears to play no role here.

KW - Alcohol

KW - Breast cancer

KW - CYP19

KW - CYP1B1

UR - https://www.scopus.com/pages/publications/0037430056

U2 - 10.1038/sj.bjc.6600761

DO - 10.1038/sj.bjc.6600761

M3 - Article

C2 - 12618873

AN - SCOPUS:0037430056

SN - 0007-0920

VL - 88

SP - 675

EP - 678

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

ER -

Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

Abstract

UN SDGs

Keywords

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