Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates

Su Young Kim; Byung Woo Jhun; Seong Mi Moon; Kyeongman Jeon; O. Jung Kwon; Hee Jae Huh; Nam Yong Lee; Sung Jae Shin; Charles L. Daley; Won Jung Koh

doi:10.1016/j.diagmicrobio.2018.10.022

Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates

Su Young Kim, Byung Woo Jhun, Seong Mi Moon, Kyeongman Jeon, O. Jung Kwon, Hee Jae Huh, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Won Jung Koh

Department of Laboratory Medicine and Genetics

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.

Original language	English
Pages (from-to)	38-40
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	94
Issue number	1
DOIs	https://doi.org/10.1016/j.diagmicrobio.2018.10.022
State	Published - May 2019

Keywords

Drug resistance
Linezolid
Mycobacterium abscessus
Mycobacterium avium complex
Nontuberculous mycobacteria

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2018.10.022

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title = "Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates",

abstract = "There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.",

keywords = "Drug resistance, Linezolid, Mycobacterium abscessus, Mycobacterium avium complex, Nontuberculous mycobacteria",

author = "Kim, \{Su Young\} and Jhun, \{Byung Woo\} and Moon, \{Seong Mi\} and Kyeongman Jeon and Kwon, \{O. Jung\} and Huh, \{Hee Jae\} and Lee, \{Nam Yong\} and Shin, \{Sung Jae\} and Daley, \{Charles L.\} and Koh, \{Won Jung\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = may,

doi = "10.1016/j.diagmicrobio.2018.10.022",

language = "English",

volume = "94",

pages = "38--40",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates

AU - Kim, Su Young

AU - Jhun, Byung Woo

AU - Moon, Seong Mi

AU - Jeon, Kyeongman

AU - Kwon, O. Jung

AU - Huh, Hee Jae

AU - Lee, Nam Yong

AU - Shin, Sung Jae

AU - Daley, Charles L.

AU - Koh, Won Jung

PY - 2019/5

Y1 - 2019/5

N2 - There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.

AB - There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.

KW - Drug resistance

KW - Linezolid

KW - Mycobacterium abscessus

KW - Mycobacterium avium complex

KW - Nontuberculous mycobacteria

UR - https://www.scopus.com/pages/publications/85058696741

U2 - 10.1016/j.diagmicrobio.2018.10.022

DO - 10.1016/j.diagmicrobio.2018.10.022

M3 - Article

C2 - 30581010

AN - SCOPUS:85058696741

SN - 0732-8893

VL - 94

SP - 38

EP - 40

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 1

ER -

Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates

Abstract

Keywords

UN SDGs

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