Genetic and environmental influences on the associations between change in kidney function and changes in cardiometabolic factors in Koreans

Yun Mi Song; Joohon Sung; Kayoung Lee

doi:10.1007/s10157-016-1295-3

Genetic and environmental influences on the associations between change in kidney function and changes in cardiometabolic factors in Koreans

Yun Mi Song
, Joohon Sung
, Kayoung Lee

Department of Family Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: This study aimed to evaluate genetic and environmental relations between change in estimated glomerular filtration rate (eGFR) and changes in cardiometabolic factors. Methods: In 1772 Korean adults without diabetes and chronic kidney disease at baseline, changes in eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation, blood pressure (BP), fasting serum glucose (FSG), insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), hemoglobin A1c, triglycerides, high and low density lipoprotein cholesterol (HDL and LDL), uric acid, white blood cell (WBC) count, and body mass index (BMI) were calculated as follows: (value at follow-up − value at baseline) × 100/[value at baseline × follow-up interval (years)]. Results: eGFR change was associated with 10 % changes in FSG (Odds ratio, OR = 1.36), uric acid (OR = 2.49), HDL (OR = 0.69), LDL (OR = 1.26), and WBC (OR = 1.15) after adjusting for age, sex, intra-familial and twin correlations, smoking, alcohol use, and physical activity at baseline, and BMI change using a generalized estimating equation. In bivariate variance-component analysis, eGFR change had additive genetic correlations (ρ_G) with changes in insulin (−0.26), HOMA-IR (−0.24), diastolic BP (−0.15), uric acid (−0.45), triglycerides (−0.30), WBC (−0.46), and HDL (0.41), and environmental correlations (ρ_E) with changes in FSG (−0.11), uric acid (−0.32), LDL (−0.14), and WBC (0.10). In co-twin control analyses in 319 monozygotic twin pairs, the ORs for having a greater eGFR decline with a 1 % increase in diastolic BP, uric acid, and LDL were 1.04, 1.09, and 1.03, respectively after adjusting for change in BMI and health behaviors at baseline. Conclusions: In these Korean twins and families, additive genetic influences and environmental effects play significant roles in the associations between eGFR change and changes in cardiometabolic factors.

Original language	English
Pages (from-to)	474-480
Number of pages	7
Journal	Clinical and Experimental Nephrology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1007/s10157-016-1295-3
State	Published - 1 Jun 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cardiometabolic trait
Change
Genetic pleiotropy
GFR
Kidney function

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10.1007/s10157-016-1295-3

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@article{7d3169325de2406388e58d3c9479d97b,

title = "Genetic and environmental influences on the associations between change in kidney function and changes in cardiometabolic factors in Koreans",

abstract = "Background: This study aimed to evaluate genetic and environmental relations between change in estimated glomerular filtration rate (eGFR) and changes in cardiometabolic factors. Methods: In 1772 Korean adults without diabetes and chronic kidney disease at baseline, changes in eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation, blood pressure (BP), fasting serum glucose (FSG), insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), hemoglobin A1c, triglycerides, high and low density lipoprotein cholesterol (HDL and LDL), uric acid, white blood cell (WBC) count, and body mass index (BMI) were calculated as follows: (value at follow-up − value at baseline) × 100/[value at baseline × follow-up interval (years)]. Results: eGFR change was associated with 10 \% changes in FSG (Odds ratio, OR = 1.36), uric acid (OR = 2.49), HDL (OR = 0.69), LDL (OR = 1.26), and WBC (OR = 1.15) after adjusting for age, sex, intra-familial and twin correlations, smoking, alcohol use, and physical activity at baseline, and BMI change using a generalized estimating equation. In bivariate variance-component analysis, eGFR change had additive genetic correlations (ρG) with changes in insulin (−0.26), HOMA-IR (−0.24), diastolic BP (−0.15), uric acid (−0.45), triglycerides (−0.30), WBC (−0.46), and HDL (0.41), and environmental correlations (ρE) with changes in FSG (−0.11), uric acid (−0.32), LDL (−0.14), and WBC (0.10). In co-twin control analyses in 319 monozygotic twin pairs, the ORs for having a greater eGFR decline with a 1 \% increase in diastolic BP, uric acid, and LDL were 1.04, 1.09, and 1.03, respectively after adjusting for change in BMI and health behaviors at baseline. Conclusions: In these Korean twins and families, additive genetic influences and environmental effects play significant roles in the associations between eGFR change and changes in cardiometabolic factors.",

keywords = "Cardiometabolic trait, Change, Genetic pleiotropy, GFR, Kidney function",

author = "Song, \{Yun Mi\} and Joohon Sung and Kayoung Lee",

note = "Publisher Copyright: {\textcopyright} 2016, Japanese Society of Nephrology.",

year = "2017",

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doi = "10.1007/s10157-016-1295-3",

language = "English",

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pages = "474--480",

journal = "Clinical and Experimental Nephrology",

issn = "1342-1751",

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TY - JOUR

T1 - Genetic and environmental influences on the associations between change in kidney function and changes in cardiometabolic factors in Koreans

AU - Song, Yun Mi

AU - Sung, Joohon

AU - Lee, Kayoung

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: This study aimed to evaluate genetic and environmental relations between change in estimated glomerular filtration rate (eGFR) and changes in cardiometabolic factors. Methods: In 1772 Korean adults without diabetes and chronic kidney disease at baseline, changes in eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation, blood pressure (BP), fasting serum glucose (FSG), insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), hemoglobin A1c, triglycerides, high and low density lipoprotein cholesterol (HDL and LDL), uric acid, white blood cell (WBC) count, and body mass index (BMI) were calculated as follows: (value at follow-up − value at baseline) × 100/[value at baseline × follow-up interval (years)]. Results: eGFR change was associated with 10 % changes in FSG (Odds ratio, OR = 1.36), uric acid (OR = 2.49), HDL (OR = 0.69), LDL (OR = 1.26), and WBC (OR = 1.15) after adjusting for age, sex, intra-familial and twin correlations, smoking, alcohol use, and physical activity at baseline, and BMI change using a generalized estimating equation. In bivariate variance-component analysis, eGFR change had additive genetic correlations (ρG) with changes in insulin (−0.26), HOMA-IR (−0.24), diastolic BP (−0.15), uric acid (−0.45), triglycerides (−0.30), WBC (−0.46), and HDL (0.41), and environmental correlations (ρE) with changes in FSG (−0.11), uric acid (−0.32), LDL (−0.14), and WBC (0.10). In co-twin control analyses in 319 monozygotic twin pairs, the ORs for having a greater eGFR decline with a 1 % increase in diastolic BP, uric acid, and LDL were 1.04, 1.09, and 1.03, respectively after adjusting for change in BMI and health behaviors at baseline. Conclusions: In these Korean twins and families, additive genetic influences and environmental effects play significant roles in the associations between eGFR change and changes in cardiometabolic factors.

AB - Background: This study aimed to evaluate genetic and environmental relations between change in estimated glomerular filtration rate (eGFR) and changes in cardiometabolic factors. Methods: In 1772 Korean adults without diabetes and chronic kidney disease at baseline, changes in eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation, blood pressure (BP), fasting serum glucose (FSG), insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), hemoglobin A1c, triglycerides, high and low density lipoprotein cholesterol (HDL and LDL), uric acid, white blood cell (WBC) count, and body mass index (BMI) were calculated as follows: (value at follow-up − value at baseline) × 100/[value at baseline × follow-up interval (years)]. Results: eGFR change was associated with 10 % changes in FSG (Odds ratio, OR = 1.36), uric acid (OR = 2.49), HDL (OR = 0.69), LDL (OR = 1.26), and WBC (OR = 1.15) after adjusting for age, sex, intra-familial and twin correlations, smoking, alcohol use, and physical activity at baseline, and BMI change using a generalized estimating equation. In bivariate variance-component analysis, eGFR change had additive genetic correlations (ρG) with changes in insulin (−0.26), HOMA-IR (−0.24), diastolic BP (−0.15), uric acid (−0.45), triglycerides (−0.30), WBC (−0.46), and HDL (0.41), and environmental correlations (ρE) with changes in FSG (−0.11), uric acid (−0.32), LDL (−0.14), and WBC (0.10). In co-twin control analyses in 319 monozygotic twin pairs, the ORs for having a greater eGFR decline with a 1 % increase in diastolic BP, uric acid, and LDL were 1.04, 1.09, and 1.03, respectively after adjusting for change in BMI and health behaviors at baseline. Conclusions: In these Korean twins and families, additive genetic influences and environmental effects play significant roles in the associations between eGFR change and changes in cardiometabolic factors.

KW - Cardiometabolic trait

KW - Change

KW - Genetic pleiotropy

KW - GFR

KW - Kidney function

UR - https://www.scopus.com/pages/publications/84976313476

U2 - 10.1007/s10157-016-1295-3

DO - 10.1007/s10157-016-1295-3

M3 - Article

C2 - 27339447

AN - SCOPUS:84976313476

SN - 1342-1751

VL - 21

SP - 474

EP - 480

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

IS - 3

ER -

Genetic and environmental influences on the associations between change in kidney function and changes in cardiometabolic factors in Koreans

Abstract

UN SDGs

Keywords

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