Further understanding of fat biology: Lessons from a fat fly

Joung Woo Hong; Kye Won Park

doi:10.3858/emm.2010.42.1.007

Further understanding of fat biology: Lessons from a fat fly

Joung Woo Hong
, Kye Won Park

Department of Food Science and Biotechnology

Kyung Hee University

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Obesity is a leading risk factor for insulin resistance, hypertension, hyperlipidemia, and cardiovascular complications, collectively referred to as metabolic diseases. Given the prevalence of obesity and its associated medical problems, new strategies are required to prevent or treat obesity and obesity-related metabolic effects. Here we summarize contributors of obesity, and molecular mechanisms controlling adipogenesis from studies in mammalian systems. We also discuss the possibilities of using Drosophila as a genetic model system to advance our understanding of players in fat biology.

Original language	English
Pages (from-to)	12-20
Number of pages	9
Journal	Experimental and Molecular Medicine
Volume	42
Issue number	1
DOIs	https://doi.org/10.3858/emm.2010.42.1.007
State	Published - 31 Jan 2010

Keywords

Adipocytes
Adipogenesis
Adipose tissue
Cell differentiation
Drosophila
Models, biological
Obesity
PPARγ

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3858/emm.2010.42.1.007

Cite this

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abstract = "Obesity is a leading risk factor for insulin resistance, hypertension, hyperlipidemia, and cardiovascular complications, collectively referred to as metabolic diseases. Given the prevalence of obesity and its associated medical problems, new strategies are required to prevent or treat obesity and obesity-related metabolic effects. Here we summarize contributors of obesity, and molecular mechanisms controlling adipogenesis from studies in mammalian systems. We also discuss the possibilities of using Drosophila as a genetic model system to advance our understanding of players in fat biology.",

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AB - Obesity is a leading risk factor for insulin resistance, hypertension, hyperlipidemia, and cardiovascular complications, collectively referred to as metabolic diseases. Given the prevalence of obesity and its associated medical problems, new strategies are required to prevent or treat obesity and obesity-related metabolic effects. Here we summarize contributors of obesity, and molecular mechanisms controlling adipogenesis from studies in mammalian systems. We also discuss the possibilities of using Drosophila as a genetic model system to advance our understanding of players in fat biology.

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KW - Adipogenesis

KW - Adipose tissue

KW - Cell differentiation

KW - Drosophila

KW - Models, biological

KW - Obesity

KW - PPARγ

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Further understanding of fat biology: Lessons from a fat fly

Abstract

Keywords

UN SDGs

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