Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction

Ki Hyun Kim; Min Ah Kim; Eunjung Moon; Sun Yeou Kim; Sang Zin Choi; Mi Won Son; Kang Ro Lee

doi:10.1016/j.bmcl.2011.02.003

Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction

Ki Hyun Kim, Min Ah Kim, Eunjung Moon, Sun Yeou Kim, Sang Zin Choi, Mi Won Son, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The rhizome of Dioscorea japonica is a food and medicinal source known as 'San Yak' in Korea. Two new furostanol saponins, coreajaponins A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of D. japonica. Their structures were determined by spectroscopic methods, including 1D and 2D NMR techniques, HRMS, and chemical methods. Nerve growth factor (NGF), a crucial factor for neuronal survival and differentiation, can potentially improve neurodegenerative diseases and diabetic polyneuropathy. We evaluated the effects of isolates (1-12) on NGF induction in a C6 rat glioma cell line. Coreajaponin B (2) upregulated NGF content without significant cell toxicity, as did 6, 8, 9, and 11.

Original language	English
Pages (from-to)	2075-2078
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2011.02.003
State	Published - 1 Apr 2011

Keywords

Dioscorea japonica
Dioscoreaceae
Furostanol saponins
NGF regulation

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10.1016/j.bmcl.2011.02.003

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title = "Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction",

abstract = "The rhizome of Dioscorea japonica is a food and medicinal source known as 'San Yak' in Korea. Two new furostanol saponins, coreajaponins A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of D. japonica. Their structures were determined by spectroscopic methods, including 1D and 2D NMR techniques, HRMS, and chemical methods. Nerve growth factor (NGF), a crucial factor for neuronal survival and differentiation, can potentially improve neurodegenerative diseases and diabetic polyneuropathy. We evaluated the effects of isolates (1-12) on NGF induction in a C6 rat glioma cell line. Coreajaponin B (2) upregulated NGF content without significant cell toxicity, as did 6, 8, 9, and 11.",

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doi = "10.1016/j.bmcl.2011.02.003",

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T1 - Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction

AU - Kim, Ki Hyun

AU - Kim, Min Ah

AU - Moon, Eunjung

AU - Kim, Sun Yeou

AU - Choi, Sang Zin

AU - Son, Mi Won

AU - Lee, Kang Ro

PY - 2011/4/1

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AB - The rhizome of Dioscorea japonica is a food and medicinal source known as 'San Yak' in Korea. Two new furostanol saponins, coreajaponins A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of D. japonica. Their structures were determined by spectroscopic methods, including 1D and 2D NMR techniques, HRMS, and chemical methods. Nerve growth factor (NGF), a crucial factor for neuronal survival and differentiation, can potentially improve neurodegenerative diseases and diabetic polyneuropathy. We evaluated the effects of isolates (1-12) on NGF induction in a C6 rat glioma cell line. Coreajaponin B (2) upregulated NGF content without significant cell toxicity, as did 6, 8, 9, and 11.

KW - Dioscorea japonica

KW - Dioscoreaceae

KW - Furostanol saponins

KW - NGF regulation

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DO - 10.1016/j.bmcl.2011.02.003

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SN - 0960-894X

VL - 21

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction

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Keywords

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