TY - JOUR
T1 - Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus
AU - Song, Yun Mi
AU - Sung, Joohon
AU - Yang, Soonha
AU - Choe, Yon Ho
AU - Chang, Yun Sil
AU - Park, Won Soon
PY - 2007/8
Y1 - 2007/8
N2 - In spite of adequate immunoprophylaxis, perinatal transmission of hepatitis B virus (HBV) has not been completely eliminated. This study evaluated the factors associated with the failure of HBV immunoprophylaxis. The study participants were 144 children who were born to HBsAg-seropositive mothers of known HBeAg status and they had received HB immune globulin and HB vaccine within 24 hours after birth followed by two further administrations of HB vaccine as recommended. Seventeen of the children (11.8%) suffered immunoprophylaxis failure, defined by HBsAg-seropositivity. The rate of HBV immunoprophylaxis failure was 12%, 0%, 21%, 0%, and 27% among the children born to HBsAg-seropositive, HBeAg-seronegative, HBeAg-seropositive, undetectable HBV DNA, and detectable HBV DNA mothers, respectively. The failure of HBV immunoprophylaxis was significantly associated with maternal HBeAg-seropositivity and HBV DNA seropositivity. To identify those children at high risk of HBV immunoprophylaxis failure, maternal HBeAg and HBV DNA need to be assessed prior to childbirth.
AB - In spite of adequate immunoprophylaxis, perinatal transmission of hepatitis B virus (HBV) has not been completely eliminated. This study evaluated the factors associated with the failure of HBV immunoprophylaxis. The study participants were 144 children who were born to HBsAg-seropositive mothers of known HBeAg status and they had received HB immune globulin and HB vaccine within 24 hours after birth followed by two further administrations of HB vaccine as recommended. Seventeen of the children (11.8%) suffered immunoprophylaxis failure, defined by HBsAg-seropositivity. The rate of HBV immunoprophylaxis failure was 12%, 0%, 21%, 0%, and 27% among the children born to HBsAg-seropositive, HBeAg-seronegative, HBeAg-seropositive, undetectable HBV DNA, and detectable HBV DNA mothers, respectively. The failure of HBV immunoprophylaxis was significantly associated with maternal HBeAg-seropositivity and HBV DNA seropositivity. To identify those children at high risk of HBV immunoprophylaxis failure, maternal HBeAg and HBV DNA need to be assessed prior to childbirth.
KW - Disease transmission, vertical
KW - Hepatitis B
KW - Hepatitis B e antigens
KW - Hepatitis B surface antigens
UR - https://www.scopus.com/pages/publications/34250881028
U2 - 10.1007/s00431-006-0327-5
DO - 10.1007/s00431-006-0327-5
M3 - Article
C2 - 17120036
AN - SCOPUS:34250881028
SN - 0340-6199
VL - 166
SP - 813
EP - 818
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 8
ER -
