Expression of gonadotropin α, follicle-stimulating hormone β, and luteinizing hormone β genes of the hermaphroditic fish kryptolebias marmoratus exposed to octylphenol, 17β estradiol, and tamoxifen

  • Jae Sung Rhee
  • , Young Mi Lee
  • , Jung Soo Seo
  • , Jeonghoon Han
  • , Jae Seong Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In order to study the expression of the gonadotropin α subunit and β subunit [follicle-stimulating hormone (FSH)-β and luteinizing hormone (LH)-β] cDNAs in the hermaphroditic fish Kryptolebias marmoratus, we cloned these genes and analyzed their modulatory effects in the brain/pituitary tissue after exposure to 17β estradiol (E2), tamoxifen (TMX), and octyphenol. Gonadotropin β subunit (FSH-β and LH-β) showed E2-dependent upregulation in most hermaphrodites, whereas TMX did not show elevated expression. Octyphenol also showed a similar effect of upregulation on FSH-β expression but not for the LH-β gene. These results suggest that the expression of FSH-β and LH-β in K. marmoratus is associated with their expression on endocrine-disrupting chemicals in this species.

Original languageEnglish
Title of host publicationTrends in Comparative Endocrinology and Neurobiology
PublisherBlackwell Publishing Inc.
Pages508-511
Number of pages4
ISBN (Print)9781573316712
DOIs
StatePublished - Apr 2009
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1163
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • FSH-β
  • Gonadotropin α
  • Kryptolebias marmoratus
  • LH-β
  • Octylphenol

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