Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

Jae Hoon Ko; Eun Jeong Joo; Jin Yang Baek; Kyungmin Huh; Sun Young Cho; Cheol In Kang; Doo Ryeon Chung; Yae Jean Kim; Eun Suk Kang; Kyong Ran Peck

doi:10.1016/j.jmii.2021.03.008

Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased.

Original language	English
Pages (from-to)	983-986
Number of pages	4
Journal	Journal of Microbiology, Immunology and Infection
Volume	54
Issue number	5
DOIs	https://doi.org/10.1016/j.jmii.2021.03.008
State	Published - Oct 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antibody
Combination
COVID-19
Performance
SARS-CoV-2

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10.1016/j.jmii.2021.03.008

Cite this

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title = "Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance",

abstract = "In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100\% when pairs of kits were used. With three-kit combination, both sensitivity (99.1\%) and specificity (100\%) increased.",

keywords = "Antibody, Combination, COVID-19, Performance, SARS-CoV-2",

author = "Ko, \{Jae Hoon\} and Joo, \{Eun Jeong\} and Baek, \{Jin Yang\} and Kyungmin Huh and Cho, \{Sun Young\} and Kang, \{Cheol In\} and Chung, \{Doo Ryeon\} and Kim, \{Yae Jean\} and Kang, \{Eun Suk\} and Peck, \{Kyong Ran\}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

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doi = "10.1016/j.jmii.2021.03.008",

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volume = "54",

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T1 - Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

AU - Ko, Jae Hoon

AU - Joo, Eun Jeong

AU - Baek, Jin Yang

AU - Huh, Kyungmin

AU - Cho, Sun Young

AU - Kang, Cheol In

AU - Chung, Doo Ryeon

AU - Kim, Yae Jean

AU - Kang, Eun Suk

AU - Peck, Kyong Ran

PY - 2021/10

Y1 - 2021/10

N2 - In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased.

AB - In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased.

KW - Antibody

KW - Combination

KW - COVID-19

KW - Performance

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85103725192

U2 - 10.1016/j.jmii.2021.03.008

DO - 10.1016/j.jmii.2021.03.008

M3 - Article

C2 - 33836943

AN - SCOPUS:85103725192

SN - 1684-1182

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SP - 983

EP - 986

JO - Journal of Microbiology, Immunology and Infection

JF - Journal of Microbiology, Immunology and Infection

IS - 5

ER -

Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

Abstract

UN SDGs

Keywords

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