Estrogenic activity of persistent organic pollutants and parabens based on the stably transfected human estrogen receptor-α transcriptional activation assay (OECD TG 455)

Tae Sung Kim; Chang Yeong Kim; Hae Kyung Lee; Il Hyun Kang; Mi Gyeong Kim; Ki Kyung Jung; Yong Kwan Kwon; Hye Seon Nam; Soon Keun Hong; Hyung Sik Kim; Hae Jung Yoon; Gyu Seek Rhee

doi:10.5487/TR.2011.27.3.181

Estrogenic activity of persistent organic pollutants and parabens based on the stably transfected human estrogen receptor-α transcriptional activation assay (OECD TG 455)

Tae Sung Kim
, Chang Yeong Kim
, Hae Kyung Lee
, Il Hyun Kang
, Mi Gyeong Kim
, Ki Kyung Jung
, Yong Kwan Kwon
, Hye Seon Nam
, Soon Keun Hong
, Hyung Sik Kim
, Hae Jung Yoon
, Gyu Seek Rhee

Research output: Contribution to journal › Short survey › peer-review

23 Scopus citations

Abstract

Screening of estrogenic activity on dichloro diphenyl trichloroethane (DDT), dichloro diphenyl dichloro ethylene (DDE), dieldrin, heptachlor, aldrin, chlordane, lindane, polybrominated diphenyl ethers (PBDE) and parabens was compared using Organization for Economic Cooperation and Development (OECD) test guideline 455 (TG455). The estrogenic activity of DDT was 58,000-fold (PC50, 1.67 × 10^-6 M) less than 17β-estradiol(E₂) (PC₅₀, 2.88 × 10^-11 M) but DDE, dieldrin, heptachlor, aldrin, chlordane, lindane and PBDE did not show any estrogenic activity in this assay system. In the case of paraben compounds, the rank of relative transcriptional activation (logRTA) was butyl paraben -1.63752 (PC₅₀, 1.25 × 10^-7M) > isobutyl paraben -2.34008 (PC₅₀, 6.3 × 10^-7M) > ethyl paraben -2.64016 (PC₅₀, 1.26 × 10^-6 M) > isopropyl paraben -2.73993 (PC₅₀, 1.58 × 10^-6M) > propyl paraben -2.84164 (PC₅₀, 2.0 × 10^-6 M). Our data suggest that OECD test guideline TG455 may be useful as a screening tool for potential endocrine disruptors.

Original language	English
Pages (from-to)	181-184
Number of pages	4
Journal	Toxicological Research
Volume	27
Issue number	3
DOIs	https://doi.org/10.5487/TR.2011.27.3.181
State	Published - Sep 2011
Externally published	Yes

Keywords

Ddt
Endocrine disruptors
Estrogenic activity
OECD test guideline 455
Parabens

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10.5487/TR.2011.27.3.181

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Kim, T. S., Kim, C. Y., Lee, H. K., Kang, I. H., Kim, M. G., Jung, K. K., Kwon, Y. K., Nam, H. S., Hong, S. K., Kim, H. S., Yoon, H. J., & Rhee, G. S. (2011). Estrogenic activity of persistent organic pollutants and parabens based on the stably transfected human estrogen receptor-α transcriptional activation assay (OECD TG 455). Toxicological Research, 27(3), 181-184. https://doi.org/10.5487/TR.2011.27.3.181

@article{81861607efd74a0781092b471ea1df66,

title = "Estrogenic activity of persistent organic pollutants and parabens based on the stably transfected human estrogen receptor-α transcriptional activation assay (OECD TG 455)",

abstract = "Screening of estrogenic activity on dichloro diphenyl trichloroethane (DDT), dichloro diphenyl dichloro ethylene (DDE), dieldrin, heptachlor, aldrin, chlordane, lindane, polybrominated diphenyl ethers (PBDE) and parabens was compared using Organization for Economic Cooperation and Development (OECD) test guideline 455 (TG455). The estrogenic activity of DDT was 58,000-fold (PC50, 1.67 × 10-6 M) less than 17β-estradiol(E2) (PC50, 2.88 × 10-11 M) but DDE, dieldrin, heptachlor, aldrin, chlordane, lindane and PBDE did not show any estrogenic activity in this assay system. In the case of paraben compounds, the rank of relative transcriptional activation (logRTA) was butyl paraben -1.63752 (PC50, 1.25 × 10-7M) > isobutyl paraben -2.34008 (PC50, 6.3 × 10-7M) > ethyl paraben -2.64016 (PC50, 1.26 × 10-6 M) > isopropyl paraben -2.73993 (PC50, 1.58 × 10-6M) > propyl paraben -2.84164 (PC50, 2.0 × 10-6 M). Our data suggest that OECD test guideline TG455 may be useful as a screening tool for potential endocrine disruptors.",

keywords = "Ddt, Endocrine disruptors, Estrogenic activity, OECD test guideline 455, Parabens",

author = "Kim, \{Tae Sung\} and Kim, \{Chang Yeong\} and Lee, \{Hae Kyung\} and Kang, \{Il Hyun\} and Kim, \{Mi Gyeong\} and Jung, \{Ki Kyung\} and Kwon, \{Yong Kwan\} and Nam, \{Hye Seon\} and Hong, \{Soon Keun\} and Kim, \{Hyung Sik\} and Yoon, \{Hae Jung\} and Rhee, \{Gyu Seek\}",

year = "2011",

month = sep,

doi = "10.5487/TR.2011.27.3.181",

language = "English",

volume = "27",

pages = "181--184",

journal = "Toxicological Research",

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Kim, TS, Kim, CY, Lee, HK, Kang, IH, Kim, MG, Jung, KK, Kwon, YK, Nam, HS, Hong, SK, Kim, HS, Yoon, HJ & Rhee, GS 2011, 'Estrogenic activity of persistent organic pollutants and parabens based on the stably transfected human estrogen receptor-α transcriptional activation assay (OECD TG 455)', Toxicological Research, vol. 27, no. 3, pp. 181-184. https://doi.org/10.5487/TR.2011.27.3.181

TY - JOUR

T1 - Estrogenic activity of persistent organic pollutants and parabens based on the stably transfected human estrogen receptor-α transcriptional activation assay (OECD TG 455)

AU - Kim, Tae Sung

AU - Kim, Chang Yeong

AU - Lee, Hae Kyung

AU - Kang, Il Hyun

AU - Kim, Mi Gyeong

AU - Jung, Ki Kyung

AU - Kwon, Yong Kwan

AU - Nam, Hye Seon

AU - Hong, Soon Keun

AU - Kim, Hyung Sik

AU - Yoon, Hae Jung

AU - Rhee, Gyu Seek

PY - 2011/9

Y1 - 2011/9

N2 - Screening of estrogenic activity on dichloro diphenyl trichloroethane (DDT), dichloro diphenyl dichloro ethylene (DDE), dieldrin, heptachlor, aldrin, chlordane, lindane, polybrominated diphenyl ethers (PBDE) and parabens was compared using Organization for Economic Cooperation and Development (OECD) test guideline 455 (TG455). The estrogenic activity of DDT was 58,000-fold (PC50, 1.67 × 10-6 M) less than 17β-estradiol(E2) (PC50, 2.88 × 10-11 M) but DDE, dieldrin, heptachlor, aldrin, chlordane, lindane and PBDE did not show any estrogenic activity in this assay system. In the case of paraben compounds, the rank of relative transcriptional activation (logRTA) was butyl paraben -1.63752 (PC50, 1.25 × 10-7M) > isobutyl paraben -2.34008 (PC50, 6.3 × 10-7M) > ethyl paraben -2.64016 (PC50, 1.26 × 10-6 M) > isopropyl paraben -2.73993 (PC50, 1.58 × 10-6M) > propyl paraben -2.84164 (PC50, 2.0 × 10-6 M). Our data suggest that OECD test guideline TG455 may be useful as a screening tool for potential endocrine disruptors.

AB - Screening of estrogenic activity on dichloro diphenyl trichloroethane (DDT), dichloro diphenyl dichloro ethylene (DDE), dieldrin, heptachlor, aldrin, chlordane, lindane, polybrominated diphenyl ethers (PBDE) and parabens was compared using Organization for Economic Cooperation and Development (OECD) test guideline 455 (TG455). The estrogenic activity of DDT was 58,000-fold (PC50, 1.67 × 10-6 M) less than 17β-estradiol(E2) (PC50, 2.88 × 10-11 M) but DDE, dieldrin, heptachlor, aldrin, chlordane, lindane and PBDE did not show any estrogenic activity in this assay system. In the case of paraben compounds, the rank of relative transcriptional activation (logRTA) was butyl paraben -1.63752 (PC50, 1.25 × 10-7M) > isobutyl paraben -2.34008 (PC50, 6.3 × 10-7M) > ethyl paraben -2.64016 (PC50, 1.26 × 10-6 M) > isopropyl paraben -2.73993 (PC50, 1.58 × 10-6M) > propyl paraben -2.84164 (PC50, 2.0 × 10-6 M). Our data suggest that OECD test guideline TG455 may be useful as a screening tool for potential endocrine disruptors.

KW - Ddt

KW - Endocrine disruptors

KW - Estrogenic activity

KW - OECD test guideline 455

KW - Parabens

UR - https://www.scopus.com/pages/publications/84865660413

U2 - 10.5487/TR.2011.27.3.181

DO - 10.5487/TR.2011.27.3.181

M3 - Short survey

AN - SCOPUS:84865660413

SN - 1976-8257

VL - 27

SP - 181

EP - 184

JO - Toxicological Research

JF - Toxicological Research

IS - 3

ER -

Estrogenic activity of persistent organic pollutants and parabens based on the stably transfected human estrogen receptor-α transcriptional activation assay (OECD TG 455)

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Keywords

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