Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria

Kyuha Chong; Taeyun Ku; Phei Er Saw; Sangyong Jon; Ji Ho Park; Chulhee Choi

doi:10.1039/c3cc46166a

Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria

Kyuha Chong, Taeyun Ku, Phei Er Saw, Sangyong Jon, Ji Ho Park, Chulhee Choi

Korea Advanced Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.

Original language	English
Pages (from-to)	11476-11478
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	98
DOIs	https://doi.org/10.1039/c3cc46166a
State	Published - 14 Nov 2013
Externally published	Yes

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10.1039/c3cc46166a

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title = "Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria",

abstract = "We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.",

author = "Kyuha Chong and Taeyun Ku and \{Er Saw\}, Phei and Sangyong Jon and Park, \{Ji Ho\} and Chulhee Choi",

year = "2013",

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doi = "10.1039/c3cc46166a",

language = "English",

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publisher = "Royal Society of Chemistry",

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T1 - Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria

AU - Chong, Kyuha

AU - Ku, Taeyun

AU - Er Saw, Phei

AU - Jon, Sangyong

AU - Park, Ji Ho

AU - Choi, Chulhee

PY - 2013/11/14

Y1 - 2013/11/14

N2 - We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.

AB - We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.

UR - https://www.scopus.com/pages/publications/84887884374

U2 - 10.1039/c3cc46166a

DO - 10.1039/c3cc46166a

M3 - Article

C2 - 24064984

AN - SCOPUS:84887884374

SN - 1359-7345

VL - 49

SP - 11476

EP - 11478

JO - Chemical Communications

JF - Chemical Communications

IS - 98

ER -

Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria

Abstract

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