Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer

Sang Hyub Lee; Ji Kon Ryu; Kyeung Yeup Lee; Sang Myung Woo; Joo Kyung Park; Ji Won Yoo; Yong Tae Kim; Yong Bum Yoon

doi:10.1016/j.canlet.2007.09.015

Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer

Sang Hyub Lee
, Ji Kon Ryu
, Kyeung Yeup Lee
, Sang Myung Woo
, Joo Kyung Park
, Ji Won Yoo
, Yong Tae Kim
, Yong Bum Yoon

Seoul National University

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-κB activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-κB activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-κB activity suppression and apoptosis induction.

Original language	English
Pages (from-to)	39-49
Number of pages	11
Journal	Cancer Letters
Volume	259
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2007.09.015
State	Published - 18 Jan 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Akt
Apigenin
Gemcitabine
NF-κB
Pancreatic cancer

Access to Document

10.1016/j.canlet.2007.09.015

Cite this

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title = "Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer",

abstract = "Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-κB activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-κB activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-κB activity suppression and apoptosis induction.",

keywords = "Akt, Apigenin, Gemcitabine, NF-κB, Pancreatic cancer",

author = "Lee, \{Sang Hyub\} and Ryu, \{Ji Kon\} and Lee, \{Kyeung Yeup\} and Woo, \{Sang Myung\} and Park, \{Joo Kyung\} and Yoo, \{Ji Won\} and Kim, \{Yong Tae\} and Yoon, \{Yong Bum\}",

year = "2008",

month = jan,

day = "18",

doi = "10.1016/j.canlet.2007.09.015",

language = "English",

volume = "259",

pages = "39--49",

journal = "Cancer Letters",

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}

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T1 - Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer

AU - Lee, Sang Hyub

AU - Ryu, Ji Kon

AU - Lee, Kyeung Yeup

AU - Woo, Sang Myung

AU - Park, Joo Kyung

AU - Yoo, Ji Won

AU - Kim, Yong Tae

AU - Yoon, Yong Bum

PY - 2008/1/18

Y1 - 2008/1/18

N2 - Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-κB activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-κB activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-κB activity suppression and apoptosis induction.

AB - Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-κB activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-κB activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-κB activity suppression and apoptosis induction.

KW - Akt

KW - Apigenin

KW - Gemcitabine

KW - NF-κB

KW - Pancreatic cancer

UR - https://www.scopus.com/pages/publications/36849075271

U2 - 10.1016/j.canlet.2007.09.015

DO - 10.1016/j.canlet.2007.09.015

M3 - Article

C2 - 17967505

AN - SCOPUS:36849075271

SN - 0304-3835

VL - 259

SP - 39

EP - 49

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer

Abstract

UN SDGs

Keywords

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