@inproceedings{497c4dd85c4647498374f3b121353dd2,
title = "Engineered 3D vascularized neurosphere-derived from induced neural stem cell in an injection-molded microfluidic array",
abstract = "In vitro platforms for studying the human brain have been developed, and brain organoids using stem cells have been actively studied. However, current organoids are not vascularized and it causes limitation of size and necrosis. Here, we have developed microfluidic array to engineer 3D vascular network with spheroid/organoid using injection molding process. We vascularized neurosphere derived from induced neural stem cells and confirmed structural and functional vessels with microbeads and confocal imaging. This platform can be applied to study the interaction between blood vessels and neurospheres, and ultimately study brain development and disease model.",
keywords = "3D vascular network, Induced neural stem cell(iNSC), Microfluidics, Neurosphere",
author = "Youngtaek Kim and Nari Shin and Jihoon Ko and Jungho Ahn and Kang, \{Kyung Sun\} and Jeon, \{Noo Li\}",
note = "Publisher Copyright: {\textcopyright} 2019 CBMS-0001.; 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",
year = "2019",
language = "English",
series = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
publisher = "Chemical and Biological Microsystems Society",
pages = "1518--1519",
booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
}