Effects of repetitive transcranial magnetic stimulation on freezing of gait in patients with Parkinsonism

Seung Yeol Lee; Min Su Kim; Won Hyuk Chang; Jin Whan Cho; Jin Young Youn; Yun Hee Kim

doi:10.3233/RNN-140397

Effects of repetitive transcranial magnetic stimulation on freezing of gait in patients with Parkinsonism

Seung Yeol Lee, Min Su Kim, Won Hyuk Chang, Jin Whan Cho, Jin Young Youn, Yun Hee Kim

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Purpose: The aim of this study was to investigate the site-specific effects of repetitive transcranial magnetic stimulation (rTMS) on freezing of gait (FOG) in patients with parkinsonism.

Methods: Twenty patients with parkinsonism and FOG were included. A single session of 10 Hz rTMS was applied over three different cortical regions of the dominant hemisphere: the primary motor cortex of the lower leg (M1-LL), the supplementary motor area (SMA), and the dorsolateral prefrontal cortex (DLPFC). We also performed sham stimulation as a control. The Timed Up and Go (TUG) test, Turn Steps and Turn Time in 180° turning, Unified Parkinson's Disease Rating Scale (UPDRS) part III, FOG Questionnaire (FOG-Q), and motor evoked potential (MEP) studies were performed before and after each intervention.

Results: There were significant improvements in TUG test times after rTMS over the M1-LL and the DLPFC. Improvement was significantly greater after the M1-LL stimulation than sham condition. The M1-LL and DLPFC stimulation also resulted in significant improvements in both the number of Turn Steps and Turn Time. UPDRS-III scores were significantly decreased after the M1-LL and DLPFC stimulation.

Conclusions: Use of 10 Hz rTMS on the M1-LL and DLPFC is therapeutically effective for FOG in patients with parkinsonism.

Original language	English
Pages (from-to)	743-753
Number of pages	11
Journal	Restorative Neurology and Neuroscience
Volume	32
Issue number	6
DOIs	https://doi.org/10.3233/RNN-140397
State	Published - 2014

Keywords

Freezing of gait
Parkinsonism
repetitive transcranial magnetic stimulation

Access to Document

10.3233/RNN-140397

Cite this

@article{1f093fcd44df4a6483d12148b6f7d374,

title = "Effects of repetitive transcranial magnetic stimulation on freezing of gait in patients with Parkinsonism",

abstract = "Purpose: The aim of this study was to investigate the site-specific effects of repetitive transcranial magnetic stimulation (rTMS) on freezing of gait (FOG) in patients with parkinsonism.Methods: Twenty patients with parkinsonism and FOG were included. A single session of 10 Hz rTMS was applied over three different cortical regions of the dominant hemisphere: the primary motor cortex of the lower leg (M1-LL), the supplementary motor area (SMA), and the dorsolateral prefrontal cortex (DLPFC). We also performed sham stimulation as a control. The Timed Up and Go (TUG) test, Turn Steps and Turn Time in 180° turning, Unified Parkinson's Disease Rating Scale (UPDRS) part III, FOG Questionnaire (FOG-Q), and motor evoked potential (MEP) studies were performed before and after each intervention.Results: There were significant improvements in TUG test times after rTMS over the M1-LL and the DLPFC. Improvement was significantly greater after the M1-LL stimulation than sham condition. The M1-LL and DLPFC stimulation also resulted in significant improvements in both the number of Turn Steps and Turn Time. UPDRS-III scores were significantly decreased after the M1-LL and DLPFC stimulation.Conclusions: Use of 10 Hz rTMS on the M1-LL and DLPFC is therapeutically effective for FOG in patients with parkinsonism.",

keywords = "Freezing of gait, Parkinsonism, repetitive transcranial magnetic stimulation",

author = "Lee, \{Seung Yeol\} and Kim, \{Min Su\} and Chang, \{Won Hyuk\} and Cho, \{Jin Whan\} and Youn, \{Jin Young\} and Kim, \{Yun Hee\}",

note = "Publisher Copyright: {\textcopyright} 2014-IOS Press and the authors.",

year = "2014",

doi = "10.3233/RNN-140397",

language = "English",

volume = "32",

pages = "743--753",

journal = "Restorative Neurology and Neuroscience",

issn = "0922-6028",

publisher = "SAGE Publications Ltd",

number = "6",

}

TY - JOUR

T1 - Effects of repetitive transcranial magnetic stimulation on freezing of gait in patients with Parkinsonism

AU - Lee, Seung Yeol

AU - Kim, Min Su

AU - Chang, Won Hyuk

AU - Cho, Jin Whan

AU - Youn, Jin Young

AU - Kim, Yun Hee

PY - 2014

Y1 - 2014

N2 - Purpose: The aim of this study was to investigate the site-specific effects of repetitive transcranial magnetic stimulation (rTMS) on freezing of gait (FOG) in patients with parkinsonism.Methods: Twenty patients with parkinsonism and FOG were included. A single session of 10 Hz rTMS was applied over three different cortical regions of the dominant hemisphere: the primary motor cortex of the lower leg (M1-LL), the supplementary motor area (SMA), and the dorsolateral prefrontal cortex (DLPFC). We also performed sham stimulation as a control. The Timed Up and Go (TUG) test, Turn Steps and Turn Time in 180° turning, Unified Parkinson's Disease Rating Scale (UPDRS) part III, FOG Questionnaire (FOG-Q), and motor evoked potential (MEP) studies were performed before and after each intervention.Results: There were significant improvements in TUG test times after rTMS over the M1-LL and the DLPFC. Improvement was significantly greater after the M1-LL stimulation than sham condition. The M1-LL and DLPFC stimulation also resulted in significant improvements in both the number of Turn Steps and Turn Time. UPDRS-III scores were significantly decreased after the M1-LL and DLPFC stimulation.Conclusions: Use of 10 Hz rTMS on the M1-LL and DLPFC is therapeutically effective for FOG in patients with parkinsonism.

AB - Purpose: The aim of this study was to investigate the site-specific effects of repetitive transcranial magnetic stimulation (rTMS) on freezing of gait (FOG) in patients with parkinsonism.Methods: Twenty patients with parkinsonism and FOG were included. A single session of 10 Hz rTMS was applied over three different cortical regions of the dominant hemisphere: the primary motor cortex of the lower leg (M1-LL), the supplementary motor area (SMA), and the dorsolateral prefrontal cortex (DLPFC). We also performed sham stimulation as a control. The Timed Up and Go (TUG) test, Turn Steps and Turn Time in 180° turning, Unified Parkinson's Disease Rating Scale (UPDRS) part III, FOG Questionnaire (FOG-Q), and motor evoked potential (MEP) studies were performed before and after each intervention.Results: There were significant improvements in TUG test times after rTMS over the M1-LL and the DLPFC. Improvement was significantly greater after the M1-LL stimulation than sham condition. The M1-LL and DLPFC stimulation also resulted in significant improvements in both the number of Turn Steps and Turn Time. UPDRS-III scores were significantly decreased after the M1-LL and DLPFC stimulation.Conclusions: Use of 10 Hz rTMS on the M1-LL and DLPFC is therapeutically effective for FOG in patients with parkinsonism.

KW - Freezing of gait

KW - Parkinsonism

KW - repetitive transcranial magnetic stimulation

UR - https://www.scopus.com/pages/publications/84910627342

U2 - 10.3233/RNN-140397

DO - 10.3233/RNN-140397

M3 - Article

C2 - 25079979

AN - SCOPUS:84910627342

SN - 0922-6028

VL - 32

SP - 743

EP - 753

JO - Restorative Neurology and Neuroscience

JF - Restorative Neurology and Neuroscience

IS - 6

ER -

Effects of repetitive transcranial magnetic stimulation on freezing of gait in patients with Parkinsonism

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this