Abstract
A traditional Korean medicine, Silsosangami (SSG), consisting of seven different herbs of Typhae Pollen, Pteropi Faeces, Paeoniae Radicis rubra, Cnidii Rhizoma, Persicae Semen, Carthami Flos and Curcumae Tuber, has been reported to have a hypolipidemic effect in human subjects. In the present study, the inhibitory effects of SSG on a thrombosis in rats, induced by endotoxin treatment were examined. The anti-thrombic properties of SSG were also investigated with respect to blood parameters. The extracts of SSG and five of the seven herbs, except Cnidii Rhizoma and Carthami Flos, inhibited both endotoxin-induced disseminated intravascular coagulation (DIC) and thrombosis in rats. The extract also inhibited the endotoxin-induced decrease in blood platelets and fibrinogen, and the endotoxin-induced increase in fibrin degradation products (FDP) on disseminated intravascular coagulation in normal rats. In conclusion, the artificially induced, protective effects of SSG on ischemic infarction might be related to their inhibitory effects on DIC, platelet coagulation and thrombotic action.
| Original language | English |
|---|---|
| Pages (from-to) | 224-229 |
| Number of pages | 6 |
| Journal | Phytotherapy Research |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2004 |
| Externally published | Yes |
Keywords
- Antithrombosis
- Blood platelet aggregation
- Carthami Flos
- Cnidii Rhizoma
- Curcumae Tuber
- Endotoxin-induced DIC
- Fibrin
- Paeoniae Radicis rubra
- Persicae Semen
- Plasminogen
- Platelet aggregation
- Pteropi Faeces
- Silsosangami
- Thrombin, fibrinogen
- Typhae Pollen