Effect of saikosaponin A on maintenance of intravenous morphine self-administration

Seong Shoon Yoon; Hey Soo Kim; Hea Young Cho; Jaesuk Yun; Eun Yong Chung; Choon Gon Jang; Kwang Joong Kim; Chae Ha Yang

doi:10.1016/j.neulet.2012.08.075

Effect of saikosaponin A on maintenance of intravenous morphine self-administration

Seong Shoon Yoon, Hey Soo Kim, Hea Young Cho, Jaesuk Yun, Eun Yong Chung, Choon Gon Jang, Kwang Joong Kim, Chae Ha Yang

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In this study, we investigated the effects of saikosaponin A (SSA), a major compound of Bupleurum falcatum L., on morphine self-administration behavior. Male Sprague-Dawley rats were trained to self-administer intravenous morphine (0.1mg/kg per injection over 5s) during daily 1-h sessions under a fixed-ratio 1 schedule. Rats were pretreated with SSA (0.25, 0.5, 1.0mg/kg) by intraperitoneal injection 30min prior to the start of the test session. Results demonstrated that pretreatment with SSA reduced morphine-maintained responding dose-dependently. Additionally, SSA inhibition of morphine-reinforced behavior was blocked by the selective GABA_B receptor antagonist (2S)(+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911), but not the selective GABA_A receptor antagonist bicuculline. Together, these results suggest that SSA may effectively suppress morphine-reinforced behavior by activating GABA_B receptors.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Neuroscience Letters
Volume	529
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2012.08.075
State	Published - 31 Oct 2012

Keywords

GABA receptor
GABA receptor
Morphine
Saikosaponin A
Self-administration

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title = "Effect of saikosaponin A on maintenance of intravenous morphine self-administration",

abstract = "In this study, we investigated the effects of saikosaponin A (SSA), a major compound of Bupleurum falcatum L., on morphine self-administration behavior. Male Sprague-Dawley rats were trained to self-administer intravenous morphine (0.1mg/kg per injection over 5s) during daily 1-h sessions under a fixed-ratio 1 schedule. Rats were pretreated with SSA (0.25, 0.5, 1.0mg/kg) by intraperitoneal injection 30min prior to the start of the test session. Results demonstrated that pretreatment with SSA reduced morphine-maintained responding dose-dependently. Additionally, SSA inhibition of morphine-reinforced behavior was blocked by the selective GABAB receptor antagonist (2S)(+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911), but not the selective GABAA receptor antagonist bicuculline. Together, these results suggest that SSA may effectively suppress morphine-reinforced behavior by activating GABAB receptors.",

keywords = "GABA receptor, GABA receptor, Morphine, Saikosaponin A, Self-administration",

author = "Yoon, \{Seong Shoon\} and Kim, \{Hey Soo\} and Cho, \{Hea Young\} and Jaesuk Yun and Chung, \{Eun Yong\} and Jang, \{Choon Gon\} and Kim, \{Kwang Joong\} and Yang, \{Chae Ha\}",

year = "2012",

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day = "31",

doi = "10.1016/j.neulet.2012.08.075",

language = "English",

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pages = "97--101",

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T1 - Effect of saikosaponin A on maintenance of intravenous morphine self-administration

AU - Yoon, Seong Shoon

AU - Kim, Hey Soo

AU - Cho, Hea Young

AU - Yun, Jaesuk

AU - Chung, Eun Yong

AU - Jang, Choon Gon

AU - Kim, Kwang Joong

AU - Yang, Chae Ha

PY - 2012/10/31

Y1 - 2012/10/31

N2 - In this study, we investigated the effects of saikosaponin A (SSA), a major compound of Bupleurum falcatum L., on morphine self-administration behavior. Male Sprague-Dawley rats were trained to self-administer intravenous morphine (0.1mg/kg per injection over 5s) during daily 1-h sessions under a fixed-ratio 1 schedule. Rats were pretreated with SSA (0.25, 0.5, 1.0mg/kg) by intraperitoneal injection 30min prior to the start of the test session. Results demonstrated that pretreatment with SSA reduced morphine-maintained responding dose-dependently. Additionally, SSA inhibition of morphine-reinforced behavior was blocked by the selective GABAB receptor antagonist (2S)(+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911), but not the selective GABAA receptor antagonist bicuculline. Together, these results suggest that SSA may effectively suppress morphine-reinforced behavior by activating GABAB receptors.

AB - In this study, we investigated the effects of saikosaponin A (SSA), a major compound of Bupleurum falcatum L., on morphine self-administration behavior. Male Sprague-Dawley rats were trained to self-administer intravenous morphine (0.1mg/kg per injection over 5s) during daily 1-h sessions under a fixed-ratio 1 schedule. Rats were pretreated with SSA (0.25, 0.5, 1.0mg/kg) by intraperitoneal injection 30min prior to the start of the test session. Results demonstrated that pretreatment with SSA reduced morphine-maintained responding dose-dependently. Additionally, SSA inhibition of morphine-reinforced behavior was blocked by the selective GABAB receptor antagonist (2S)(+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911), but not the selective GABAA receptor antagonist bicuculline. Together, these results suggest that SSA may effectively suppress morphine-reinforced behavior by activating GABAB receptors.

KW - GABA receptor

KW - Morphine

KW - Saikosaponin A

KW - Self-administration

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IS - 1

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Effect of saikosaponin A on maintenance of intravenous morphine self-administration

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Keywords

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