Effect of induction chemotherapy on survival in locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy: Single center experience

Chan Young Ock; Bhumsuk Keam; Yoojoo Lim; Tae Min Kim; Se Hoon Lee; Seong Keun Kwon; J. Hun Hah; Tack Kyun Kwon; Dong Wan Kim; Hong Gyun Wu; Myung Whun Sung; Dae Seog Heo

doi:10.1002/hed.23891

Effect of induction chemotherapy on survival in locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy: Single center experience

Chan Young Ock, Bhumsuk Keam, Yoojoo Lim, Tae Min Kim, Se Hoon Lee, Seong Keun Kwon, J. Hun Hah, Tack Kyun Kwon, Dong Wan Kim, Hong Gyun Wu, Myung Whun Sung, Dae Seog Heo

Seoul National University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background Although induction chemotherapy can reduce distant metastases in locally advanced head and neck squamous cell carcinoma (HNSCC), overall survival (OS) improvement because of induction chemotherapy has not been confirmed. Methods We reviewed medical records of 224 patients diagnosed with locally advanced HNSCC who were treated with induction chemotherapy followed by concurrent chemoradiotherapy (CRT; induction chemotherapy/CRT; N = 144) and CRT alone (N = 80) from 2005 to 2013. We analyzed OS and progression-free survival (PFS). Results The 3-year OS rate was significantly higher in the induction chemotherapy/CRT group compared to the CRT group (74.0% vs 62.7%; p =.045). The 3-year PFS rate was 64.6% in the induction chemotherapy/CRT group and 54.1% in the CRT group (p =.060). Subgroup analysis showed patients with high N classification (N2 or N3) oropharyngeal cancer had greater benefits when treated with induction chemotherapy/CRT. Conclusion Induction chemotherapy plus CRT improved OS, compared to CRT alone in locally advanced HNSCC, especially with high N classification.

Original language	English
Pages (from-to)	277-284
Number of pages	8
Journal	Head and Neck
Volume	38
Issue number	2
DOIs	https://doi.org/10.1002/hed.23891
State	Published - 1 Feb 2016
Externally published	Yes

Keywords

concurrent chemoradiotherapy
head and neck cancer
induction chemotherapy
subgroup analysis
survival

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10.1002/hed.23891

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Ock, C. Y., Keam, B., Lim, Y., Kim, T. M., Lee, S. H., Kwon, S. K., Hah, J. H., Kwon, T. K., Kim, D. W., Wu, H. G., Sung, M. W., & Heo, D. S. (2016). Effect of induction chemotherapy on survival in locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy: Single center experience. Head and Neck, 38(2), 277-284. https://doi.org/10.1002/hed.23891

@article{4e61121ad7b94c1b89499283d57cb9eb,

title = "Effect of induction chemotherapy on survival in locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy: Single center experience",

abstract = "Background Although induction chemotherapy can reduce distant metastases in locally advanced head and neck squamous cell carcinoma (HNSCC), overall survival (OS) improvement because of induction chemotherapy has not been confirmed. Methods We reviewed medical records of 224 patients diagnosed with locally advanced HNSCC who were treated with induction chemotherapy followed by concurrent chemoradiotherapy (CRT; induction chemotherapy/CRT; N = 144) and CRT alone (N = 80) from 2005 to 2013. We analyzed OS and progression-free survival (PFS). Results The 3-year OS rate was significantly higher in the induction chemotherapy/CRT group compared to the CRT group (74.0\% vs 62.7\%; p =.045). The 3-year PFS rate was 64.6\% in the induction chemotherapy/CRT group and 54.1\% in the CRT group (p =.060). Subgroup analysis showed patients with high N classification (N2 or N3) oropharyngeal cancer had greater benefits when treated with induction chemotherapy/CRT. Conclusion Induction chemotherapy plus CRT improved OS, compared to CRT alone in locally advanced HNSCC, especially with high N classification.",

keywords = "concurrent chemoradiotherapy, head and neck cancer, induction chemotherapy, subgroup analysis, survival",

author = "Ock, \{Chan Young\} and Bhumsuk Keam and Yoojoo Lim and Kim, \{Tae Min\} and Lee, \{Se Hoon\} and Kwon, \{Seong Keun\} and Hah, \{J. Hun\} and Kwon, \{Tack Kyun\} and Kim, \{Dong Wan\} and Wu, \{Hong Gyun\} and Sung, \{Myung Whun\} and Heo, \{Dae Seog\}",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley Periodicals, Inc. Head Neck 38: 277-284,2016",

year = "2016",

month = feb,

day = "1",

doi = "10.1002/hed.23891",

language = "English",

volume = "38",

pages = "277--284",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "2",

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TY - JOUR

T1 - Effect of induction chemotherapy on survival in locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy

T2 - Single center experience

AU - Ock, Chan Young

AU - Keam, Bhumsuk

AU - Lim, Yoojoo

AU - Kim, Tae Min

AU - Lee, Se Hoon

AU - Kwon, Seong Keun

AU - Hah, J. Hun

AU - Kwon, Tack Kyun

AU - Kim, Dong Wan

AU - Wu, Hong Gyun

AU - Sung, Myung Whun

AU - Heo, Dae Seog

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background Although induction chemotherapy can reduce distant metastases in locally advanced head and neck squamous cell carcinoma (HNSCC), overall survival (OS) improvement because of induction chemotherapy has not been confirmed. Methods We reviewed medical records of 224 patients diagnosed with locally advanced HNSCC who were treated with induction chemotherapy followed by concurrent chemoradiotherapy (CRT; induction chemotherapy/CRT; N = 144) and CRT alone (N = 80) from 2005 to 2013. We analyzed OS and progression-free survival (PFS). Results The 3-year OS rate was significantly higher in the induction chemotherapy/CRT group compared to the CRT group (74.0% vs 62.7%; p =.045). The 3-year PFS rate was 64.6% in the induction chemotherapy/CRT group and 54.1% in the CRT group (p =.060). Subgroup analysis showed patients with high N classification (N2 or N3) oropharyngeal cancer had greater benefits when treated with induction chemotherapy/CRT. Conclusion Induction chemotherapy plus CRT improved OS, compared to CRT alone in locally advanced HNSCC, especially with high N classification.

AB - Background Although induction chemotherapy can reduce distant metastases in locally advanced head and neck squamous cell carcinoma (HNSCC), overall survival (OS) improvement because of induction chemotherapy has not been confirmed. Methods We reviewed medical records of 224 patients diagnosed with locally advanced HNSCC who were treated with induction chemotherapy followed by concurrent chemoradiotherapy (CRT; induction chemotherapy/CRT; N = 144) and CRT alone (N = 80) from 2005 to 2013. We analyzed OS and progression-free survival (PFS). Results The 3-year OS rate was significantly higher in the induction chemotherapy/CRT group compared to the CRT group (74.0% vs 62.7%; p =.045). The 3-year PFS rate was 64.6% in the induction chemotherapy/CRT group and 54.1% in the CRT group (p =.060). Subgroup analysis showed patients with high N classification (N2 or N3) oropharyngeal cancer had greater benefits when treated with induction chemotherapy/CRT. Conclusion Induction chemotherapy plus CRT improved OS, compared to CRT alone in locally advanced HNSCC, especially with high N classification.

KW - concurrent chemoradiotherapy

KW - head and neck cancer

KW - induction chemotherapy

KW - subgroup analysis

KW - survival

UR - https://www.scopus.com/pages/publications/84955683252

U2 - 10.1002/hed.23891

DO - 10.1002/hed.23891

M3 - Article

C2 - 26104823

AN - SCOPUS:84955683252

SN - 1043-3074

VL - 38

SP - 277

EP - 284

JO - Head and Neck

JF - Head and Neck

IS - 2

ER -

Effect of induction chemotherapy on survival in locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy: Single center experience

Abstract

Keywords

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