Effect of high-dose aspirin on Helicobacter pylori eradication

Seung Ha Park; Dong Il Park; Sang Hoon Kim; Hong Joo Kim; Yong Kyun Cho; In Kyung Sung; Chong Il Sohn; Woo Kyu Jeon; Byung Ik Kim; Dong Keuk Keum

doi:10.1007/s10620-005-2547-3

Effect of high-dose aspirin on Helicobacter pylori eradication

Seung Ha Park, Dong Il Park, Sang Hoon Kim, Hong Joo Kim, Yong Kyun Cho, In Kyung Sung, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Dong Keuk Keum

Kangbuk Samsung Hospital

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We conducted a pilot study aimed at comparing the efficacy of the standard OAC (omeprazole-amoxicillin-clarithromycin) regimen with a combination of the OAC regimen and aspirin (OACA). Follow-up endoscopic findings showed that the previous ulcers were completely healed in all subjects. The eradication rates (per protocol) were 80.3% (49/61) in the OAC group and 86.7% (52/60) in the OACA group. The eradication rate was not significantly different between the two groups. The most common adverse event was a bad taste, and the overall adverse events were similar in the two groups. The combination of the OAC regimen and aspirin was not significantly superior to the standard OAC regimen, but it was well tolerated in a group of patients with peptic ulcer disease. Its potential for clinical use to augment the efficacy of H. pylori eradication may warrant further investigation.

Original language	English
Pages (from-to)	626-629
Number of pages	4
Journal	Digestive diseases and sciences
Volume	50
Issue number	4
DOIs	https://doi.org/10.1007/s10620-005-2547-3
State	Published - Apr 2005
Externally published	Yes

Keywords

Aspirin
Eradication
Helicobacter pylori
Peptic ulcer

Access to Document

10.1007/s10620-005-2547-3

Cite this

@article{eeb1fe52f8c6447a98a21467d9972460,

title = "Effect of high-dose aspirin on Helicobacter pylori eradication",

abstract = "We conducted a pilot study aimed at comparing the efficacy of the standard OAC (omeprazole-amoxicillin-clarithromycin) regimen with a combination of the OAC regimen and aspirin (OACA). Follow-up endoscopic findings showed that the previous ulcers were completely healed in all subjects. The eradication rates (per protocol) were 80.3\% (49/61) in the OAC group and 86.7\% (52/60) in the OACA group. The eradication rate was not significantly different between the two groups. The most common adverse event was a bad taste, and the overall adverse events were similar in the two groups. The combination of the OAC regimen and aspirin was not significantly superior to the standard OAC regimen, but it was well tolerated in a group of patients with peptic ulcer disease. Its potential for clinical use to augment the efficacy of H. pylori eradication may warrant further investigation.",

keywords = "Aspirin, Eradication, Helicobacter pylori, Peptic ulcer",

author = "Park, \{Seung Ha\} and Park, \{Dong Il\} and Kim, \{Sang Hoon\} and Kim, \{Hong Joo\} and Cho, \{Yong Kyun\} and Sung, \{In Kyung\} and Sohn, \{Chong Il\} and Jeon, \{Woo Kyu\} and Kim, \{Byung Ik\} and Keum, \{Dong Keuk\}",

year = "2005",

month = apr,

doi = "10.1007/s10620-005-2547-3",

language = "English",

volume = "50",

pages = "626--629",

journal = "Digestive diseases and sciences",

issn = "1573-2568",

number = "4",

}

TY - JOUR

T1 - Effect of high-dose aspirin on Helicobacter pylori eradication

AU - Park, Seung Ha

AU - Park, Dong Il

AU - Kim, Sang Hoon

AU - Kim, Hong Joo

AU - Cho, Yong Kyun

AU - Sung, In Kyung

AU - Sohn, Chong Il

AU - Jeon, Woo Kyu

AU - Kim, Byung Ik

AU - Keum, Dong Keuk

PY - 2005/4

Y1 - 2005/4

N2 - We conducted a pilot study aimed at comparing the efficacy of the standard OAC (omeprazole-amoxicillin-clarithromycin) regimen with a combination of the OAC regimen and aspirin (OACA). Follow-up endoscopic findings showed that the previous ulcers were completely healed in all subjects. The eradication rates (per protocol) were 80.3% (49/61) in the OAC group and 86.7% (52/60) in the OACA group. The eradication rate was not significantly different between the two groups. The most common adverse event was a bad taste, and the overall adverse events were similar in the two groups. The combination of the OAC regimen and aspirin was not significantly superior to the standard OAC regimen, but it was well tolerated in a group of patients with peptic ulcer disease. Its potential for clinical use to augment the efficacy of H. pylori eradication may warrant further investigation.

AB - We conducted a pilot study aimed at comparing the efficacy of the standard OAC (omeprazole-amoxicillin-clarithromycin) regimen with a combination of the OAC regimen and aspirin (OACA). Follow-up endoscopic findings showed that the previous ulcers were completely healed in all subjects. The eradication rates (per protocol) were 80.3% (49/61) in the OAC group and 86.7% (52/60) in the OACA group. The eradication rate was not significantly different between the two groups. The most common adverse event was a bad taste, and the overall adverse events were similar in the two groups. The combination of the OAC regimen and aspirin was not significantly superior to the standard OAC regimen, but it was well tolerated in a group of patients with peptic ulcer disease. Its potential for clinical use to augment the efficacy of H. pylori eradication may warrant further investigation.

KW - Aspirin

KW - Eradication

KW - Helicobacter pylori

KW - Peptic ulcer

UR - https://www.scopus.com/pages/publications/20244370506

U2 - 10.1007/s10620-005-2547-3

DO - 10.1007/s10620-005-2547-3

M3 - Article

C2 - 15844692

AN - SCOPUS:20244370506

SN - 1573-2568

VL - 50

SP - 626

EP - 629

JO - Digestive diseases and sciences

JF - Digestive diseases and sciences

IS - 4

ER -

Effect of high-dose aspirin on Helicobacter pylori eradication

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this