Direct etherification of alkyl halides by sodium hydride in the presence of N,N-dimethylformamide

Hua Jin Cheng; Young Lee Ho; Hwi Lee Sang; Su Kim In; Hoon Jung Young

doi:10.1055/s-2007-991068

Direct etherification of alkyl halides by sodium hydride in the presence of N,N-dimethylformamide

Hua Jin Cheng
, Young Lee Ho
, Hwi Lee Sang
, Su Kim In
, Hoon Jung Young

Department of Pharmacy

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A novel synthetic method for the preparation of various alkyl ethers is described. The reaction between alkyl halides and sodium hydride in the presence of N,N-dimethylformamide afforded the corresponding symmetrical and unsymmetrical ethers in high yields. A reaction mechanism for etherification is also proposed.

Original language	English
Pages (from-to)	2695-2698
Number of pages	4
Journal	Synlett
Issue number	17
DOIs	https://doi.org/10.1055/s-2007-991068
State	Published - 16 Oct 2007

Keywords

Alkyl halides
Dimethylformamide
Etherification
Sodium hydride
Symmetrical and unsymmetrical ethers

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10.1055/s-2007-991068

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title = "Direct etherification of alkyl halides by sodium hydride in the presence of N,N-dimethylformamide",

abstract = "A novel synthetic method for the preparation of various alkyl ethers is described. The reaction between alkyl halides and sodium hydride in the presence of N,N-dimethylformamide afforded the corresponding symmetrical and unsymmetrical ethers in high yields. A reaction mechanism for etherification is also proposed.",

keywords = "Alkyl halides, Dimethylformamide, Etherification, Sodium hydride, Symmetrical and unsymmetrical ethers",

author = "Cheng, \{Hua Jin\} and Ho, \{Young Lee\} and Sang, \{Hwi Lee\} and In, \{Su Kim\} and Young, \{Hoon Jung\}",

year = "2007",

month = oct,

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doi = "10.1055/s-2007-991068",

language = "English",

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journal = "Synlett",

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T1 - Direct etherification of alkyl halides by sodium hydride in the presence of N,N-dimethylformamide

AU - Cheng, Hua Jin

AU - Ho, Young Lee

AU - Sang, Hwi Lee

AU - In, Su Kim

AU - Young, Hoon Jung

PY - 2007/10/16

Y1 - 2007/10/16

N2 - A novel synthetic method for the preparation of various alkyl ethers is described. The reaction between alkyl halides and sodium hydride in the presence of N,N-dimethylformamide afforded the corresponding symmetrical and unsymmetrical ethers in high yields. A reaction mechanism for etherification is also proposed.

AB - A novel synthetic method for the preparation of various alkyl ethers is described. The reaction between alkyl halides and sodium hydride in the presence of N,N-dimethylformamide afforded the corresponding symmetrical and unsymmetrical ethers in high yields. A reaction mechanism for etherification is also proposed.

KW - Alkyl halides

KW - Dimethylformamide

KW - Etherification

KW - Sodium hydride

KW - Symmetrical and unsymmetrical ethers

UR - https://www.scopus.com/pages/publications/35748969124

U2 - 10.1055/s-2007-991068

DO - 10.1055/s-2007-991068

M3 - Article

AN - SCOPUS:35748969124

SN - 0936-5214

SP - 2695

EP - 2698

JO - Synlett

JF - Synlett

IS - 17

ER -

Direct etherification of alkyl halides by sodium hydride in the presence of N,N-dimethylformamide

Abstract

Keywords

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