Differential expressions of Fas and Fas ligand in human placenta.

Cheong Rae Roh; Jeong Won Lee; Byung Hee Kang; Soon Ha Yang; Byoung Gie Kim; Duk Soo Bae; Jong Hwa Kim; Je Ho Lee

doi:10.3346/jkms.2002.17.2.213

Differential expressions of Fas and Fas ligand in human placenta.

Cheong Rae Roh
, Jeong Won Lee
, Byung Hee Kang
, Soon Ha Yang
, Byoung Gie Kim
, Duk Soo Bae
, Jong Hwa Kim
, Je Ho Lee

Department of Obstetrics and Gynecology

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts respectively. The differential distribution of Fas and FasL in human placenta may reflect intrinsic expressions of them by trophoblasts during differentiation. The increased expression of Fas in trophoblasts may promote apoptosis of placenta in pathologic condition such as preeclampsia.

Original language	English
Pages (from-to)	213-216
Number of pages	4
Journal	Journal of Korean Medical Science
Volume	17
Issue number	2
DOIs	https://doi.org/10.3346/jkms.2002.17.2.213
State	Published - Apr 2002

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title = "Differential expressions of Fas and Fas ligand in human placenta.",

abstract = "To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts respectively. The differential distribution of Fas and FasL in human placenta may reflect intrinsic expressions of them by trophoblasts during differentiation. The increased expression of Fas in trophoblasts may promote apoptosis of placenta in pathologic condition such as preeclampsia.",

author = "Roh, \{Cheong Rae\} and Lee, \{Jeong Won\} and Kang, \{Byung Hee\} and Yang, \{Soon Ha\} and Kim, \{Byoung Gie\} and Bae, \{Duk Soo\} and Kim, \{Jong Hwa\} and Lee, \{Je Ho\}",

year = "2002",

month = apr,

doi = "10.3346/jkms.2002.17.2.213",

language = "English",

volume = "17",

pages = "213--216",

journal = "Journal of Korean Medical Science",

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TY - JOUR

T1 - Differential expressions of Fas and Fas ligand in human placenta.

AU - Roh, Cheong Rae

AU - Lee, Jeong Won

AU - Kang, Byung Hee

AU - Yang, Soon Ha

AU - Kim, Byoung Gie

AU - Bae, Duk Soo

AU - Kim, Jong Hwa

AU - Lee, Je Ho

PY - 2002/4

Y1 - 2002/4

N2 - To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts respectively. The differential distribution of Fas and FasL in human placenta may reflect intrinsic expressions of them by trophoblasts during differentiation. The increased expression of Fas in trophoblasts may promote apoptosis of placenta in pathologic condition such as preeclampsia.

AB - To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts respectively. The differential distribution of Fas and FasL in human placenta may reflect intrinsic expressions of them by trophoblasts during differentiation. The increased expression of Fas in trophoblasts may promote apoptosis of placenta in pathologic condition such as preeclampsia.

UR - https://www.scopus.com/pages/publications/0036551363

U2 - 10.3346/jkms.2002.17.2.213

DO - 10.3346/jkms.2002.17.2.213

M3 - Article

C2 - 11961305

AN - SCOPUS:0036551363

SN - 1011-8934

VL - 17

SP - 213

EP - 216

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 2

ER -

Differential expressions of Fas and Fas ligand in human placenta.

Abstract

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