Development of pH-responsive cyclodextrin nanoparticles for tumor-specific photodynamic therapy

Seonyoung Yoon; Gwang Jin Noh; Yu Seok Youn; Kyung Taek Oh; Eun Seong Lee

doi:10.1002/pat.5047

Development of pH-responsive cyclodextrin nanoparticles for tumor-specific photodynamic therapy

Seonyoung Yoon, Gwang Jin Noh, Yu Seok Youn, Kyung Taek Oh, Eun Seong Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In this study, we report pH-responsive porous polysaccharide nanoparticles (NPs) for tumor-specific photodynamic therapy. Herein, γ-cyclodextrin (γCD) conjugated with 3-(diethylamino)propylamine (DEAP, as a pH-responsive moiety) and poly(ethylene glycol) (PEG) was used to fabricate γCD-(DEAP/PEG) NPs using a self-assembling process with γCD and PEG as a hydrophilic segment and DEAP as a hydrophobic segment. These NPs contain rich pore channels, allowing for the facile encapsulation of chlorin e6 (Ce6, as a model drug) via host-guest supramolecular interactions. Furthermore, the DEAP moieties (pK_b ~ 7.0) in the γCD-(DEAP/PEG) NPs could be protonated at weakly acidic pH (pH 6.8) in a tumor environment. This event resulted in the rapid structural destabilization of the host γCD-(DEAP/PEG) NPs owing to the protonated DEAP moieties, thereby leading to the extensive release of the phototoxic Ce6 guest. Consequently, the Ce6-loaded γCD-(DEAP/PEG) NPs exhibited a significant inhibition of MDA-MB-231 tumor cell growth under light irradiation, demonstrating their potential as a tumor-specific photosensitizing drug carrier.

Original language	English
Pages (from-to)	3228-3237
Number of pages	10
Journal	Polymers for Advanced Technologies
Volume	31
Issue number	12
DOIs	https://doi.org/10.1002/pat.5047
State	Published - 1 Dec 2020

Keywords

pH-responsive γ-cyclodextrin nanoparticles
photodynamic tumor therapy
tumor acidic pH

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10.1002/pat.5047

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title = "Development of pH-responsive cyclodextrin nanoparticles for tumor-specific photodynamic therapy",

abstract = "In this study, we report pH-responsive porous polysaccharide nanoparticles (NPs) for tumor-specific photodynamic therapy. Herein, γ-cyclodextrin (γCD) conjugated with 3-(diethylamino)propylamine (DEAP, as a pH-responsive moiety) and poly(ethylene glycol) (PEG) was used to fabricate γCD-(DEAP/PEG) NPs using a self-assembling process with γCD and PEG as a hydrophilic segment and DEAP as a hydrophobic segment. These NPs contain rich pore channels, allowing for the facile encapsulation of chlorin e6 (Ce6, as a model drug) via host-guest supramolecular interactions. Furthermore, the DEAP moieties (pKb \textasciitilde{} 7.0) in the γCD-(DEAP/PEG) NPs could be protonated at weakly acidic pH (pH 6.8) in a tumor environment. This event resulted in the rapid structural destabilization of the host γCD-(DEAP/PEG) NPs owing to the protonated DEAP moieties, thereby leading to the extensive release of the phototoxic Ce6 guest. Consequently, the Ce6-loaded γCD-(DEAP/PEG) NPs exhibited a significant inhibition of MDA-MB-231 tumor cell growth under light irradiation, demonstrating their potential as a tumor-specific photosensitizing drug carrier.",

keywords = "pH-responsive γ-cyclodextrin nanoparticles, photodynamic tumor therapy, tumor acidic pH",

author = "Seonyoung Yoon and Noh, \{Gwang Jin\} and Youn, \{Yu Seok\} and Oh, \{Kyung Taek\} and Lee, \{Eun Seong\}",

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doi = "10.1002/pat.5047",

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AU - Yoon, Seonyoung

AU - Noh, Gwang Jin

AU - Youn, Yu Seok

AU - Oh, Kyung Taek

AU - Lee, Eun Seong

PY - 2020/12/1

Y1 - 2020/12/1

N2 - In this study, we report pH-responsive porous polysaccharide nanoparticles (NPs) for tumor-specific photodynamic therapy. Herein, γ-cyclodextrin (γCD) conjugated with 3-(diethylamino)propylamine (DEAP, as a pH-responsive moiety) and poly(ethylene glycol) (PEG) was used to fabricate γCD-(DEAP/PEG) NPs using a self-assembling process with γCD and PEG as a hydrophilic segment and DEAP as a hydrophobic segment. These NPs contain rich pore channels, allowing for the facile encapsulation of chlorin e6 (Ce6, as a model drug) via host-guest supramolecular interactions. Furthermore, the DEAP moieties (pKb ~ 7.0) in the γCD-(DEAP/PEG) NPs could be protonated at weakly acidic pH (pH 6.8) in a tumor environment. This event resulted in the rapid structural destabilization of the host γCD-(DEAP/PEG) NPs owing to the protonated DEAP moieties, thereby leading to the extensive release of the phototoxic Ce6 guest. Consequently, the Ce6-loaded γCD-(DEAP/PEG) NPs exhibited a significant inhibition of MDA-MB-231 tumor cell growth under light irradiation, demonstrating their potential as a tumor-specific photosensitizing drug carrier.

AB - In this study, we report pH-responsive porous polysaccharide nanoparticles (NPs) for tumor-specific photodynamic therapy. Herein, γ-cyclodextrin (γCD) conjugated with 3-(diethylamino)propylamine (DEAP, as a pH-responsive moiety) and poly(ethylene glycol) (PEG) was used to fabricate γCD-(DEAP/PEG) NPs using a self-assembling process with γCD and PEG as a hydrophilic segment and DEAP as a hydrophobic segment. These NPs contain rich pore channels, allowing for the facile encapsulation of chlorin e6 (Ce6, as a model drug) via host-guest supramolecular interactions. Furthermore, the DEAP moieties (pKb ~ 7.0) in the γCD-(DEAP/PEG) NPs could be protonated at weakly acidic pH (pH 6.8) in a tumor environment. This event resulted in the rapid structural destabilization of the host γCD-(DEAP/PEG) NPs owing to the protonated DEAP moieties, thereby leading to the extensive release of the phototoxic Ce6 guest. Consequently, the Ce6-loaded γCD-(DEAP/PEG) NPs exhibited a significant inhibition of MDA-MB-231 tumor cell growth under light irradiation, demonstrating their potential as a tumor-specific photosensitizing drug carrier.

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KW - photodynamic tumor therapy

KW - tumor acidic pH

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Development of pH-responsive cyclodextrin nanoparticles for tumor-specific photodynamic therapy

Abstract

Keywords

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