Development of light-driven gas-forming liposomes for efficient tumor treatment

Jae Min Lee; Yu Seok Youn; Eun Seong Lee

doi:10.1016/j.ijpharm.2017.04.046

Development of light-driven gas-forming liposomes for efficient tumor treatment

Jae Min Lee, Yu Seok Youn, Eun Seong Lee

Department of Pharmacy

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In this study, we report a gas-forming liposome containing 1H-1H-2H-perfluoro-1-hexene (PFH) and gold nanoparticles (AuNPs). These liposomes were rapidly destabilized by external near-infrared (NIR) light, as a result of the vaporization of PFH influenced by an AuNPs-mediated photothermal event. In particular, these liposomes showed the triggered release of the encapsulated D-(KLAKLAK)₂ peptide drug. The experimental results demonstrated that the light-irradiated liposomes significantly enhanced in vitro photothermal and D-(KLAKLAK)₂ peptide-mediated cell death of CAOV-3 tumor cells.

Original language	English
Pages (from-to)	218-225
Number of pages	8
Journal	International Journal of Pharmaceutics
Volume	525
Issue number	1
DOIs	https://doi.org/10.1016/j.ijpharm.2017.04.046
State	Published - 15 Jun 2017

Keywords

D-(KLAKLAK) peptide drug
Gas-forming liposome
Gold nanoparticles (AuNPs)
Perfluorohexene

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10.1016/j.ijpharm.2017.04.046

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title = "Development of light-driven gas-forming liposomes for efficient tumor treatment",

abstract = "In this study, we report a gas-forming liposome containing 1H-1H-2H-perfluoro-1-hexene (PFH) and gold nanoparticles (AuNPs). These liposomes were rapidly destabilized by external near-infrared (NIR) light, as a result of the vaporization of PFH influenced by an AuNPs-mediated photothermal event. In particular, these liposomes showed the triggered release of the encapsulated D-(KLAKLAK)2 peptide drug. The experimental results demonstrated that the light-irradiated liposomes significantly enhanced in vitro photothermal and D-(KLAKLAK)2 peptide-mediated cell death of CAOV-3 tumor cells.",

keywords = "D-(KLAKLAK) peptide drug, Gas-forming liposome, Gold nanoparticles (AuNPs), Perfluorohexene",

author = "Lee, \{Jae Min\} and Youn, \{Yu Seok\} and Lee, \{Eun Seong\}",

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year = "2017",

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doi = "10.1016/j.ijpharm.2017.04.046",

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T1 - Development of light-driven gas-forming liposomes for efficient tumor treatment

AU - Lee, Jae Min

AU - Youn, Yu Seok

AU - Lee, Eun Seong

PY - 2017/6/15

Y1 - 2017/6/15

N2 - In this study, we report a gas-forming liposome containing 1H-1H-2H-perfluoro-1-hexene (PFH) and gold nanoparticles (AuNPs). These liposomes were rapidly destabilized by external near-infrared (NIR) light, as a result of the vaporization of PFH influenced by an AuNPs-mediated photothermal event. In particular, these liposomes showed the triggered release of the encapsulated D-(KLAKLAK)2 peptide drug. The experimental results demonstrated that the light-irradiated liposomes significantly enhanced in vitro photothermal and D-(KLAKLAK)2 peptide-mediated cell death of CAOV-3 tumor cells.

AB - In this study, we report a gas-forming liposome containing 1H-1H-2H-perfluoro-1-hexene (PFH) and gold nanoparticles (AuNPs). These liposomes were rapidly destabilized by external near-infrared (NIR) light, as a result of the vaporization of PFH influenced by an AuNPs-mediated photothermal event. In particular, these liposomes showed the triggered release of the encapsulated D-(KLAKLAK)2 peptide drug. The experimental results demonstrated that the light-irradiated liposomes significantly enhanced in vitro photothermal and D-(KLAKLAK)2 peptide-mediated cell death of CAOV-3 tumor cells.

KW - D-(KLAKLAK) peptide drug

KW - Gas-forming liposome

KW - Gold nanoparticles (AuNPs)

KW - Perfluorohexene

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DO - 10.1016/j.ijpharm.2017.04.046

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SN - 0378-5173

VL - 525

SP - 218

EP - 225

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1

ER -

Development of light-driven gas-forming liposomes for efficient tumor treatment

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