Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles

Hyon Bin Na; Jung Hee Lee; Kwangjin An; Yong Il Park; Mihyun Park; In Su Lee; Do Hyun Nam; Sung Tae Kim; Seung Hoon Kim; Sang Wook Kim; Keun Ho Lim; Ki Soo Kim; Sun Ok Kim; Taeghwan Hyeon

doi:10.1002/anie.200604775

Development of a T₁ contrast agent for magnetic resonance imaging using MnO nanoparticles

Hyon Bin Na
, Jung Hee Lee
, Kwangjin An
, Yong Il Park
, Mihyun Park
, In Su Lee
, Do Hyun Nam
, Sung Tae Kim
, Seung Hoon Kim
, Sang Wook Kim
, Keun Ho Lim
, Ki Soo Kim
, Sun Ok Kim
, Taeghwan Hyeon

Department of Radiology

Seoul National University
Sungkyunkwan University
Kyung Hee University
Ajou University
University of Ulsan
Samyang Corporation

Research output: Contribution to journal › Article › peer-review

591 Scopus citations

Abstract

Contrasting images: A new T₁ contrast agent for magnetic resonance imaging (MRI) based on MnO nanoparticles reveals a bright signal enhancement and fine anatomic structures in the T₁-weighted MR image of a mouse brain (see picture; left MRI, right MnO-enhanced MRI (MONEMRI)). Furthermore, MnO nanoparticles conjugated with a tumor-specific antibody were used for selectively imaging breast cancer cells in a metastatic tumor in brain. (Figure Presented).

Original language	English
Pages (from-to)	5397-5401
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	28
DOIs	https://doi.org/10.1002/anie.200604775
State	Published - 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Contrast agents
Imaging agents
Magnetic resonance imaging
Manganese
Nanoparticles

Access to Document

10.1002/anie.200604775

Cite this

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abstract = "Contrasting images: A new T1 contrast agent for magnetic resonance imaging (MRI) based on MnO nanoparticles reveals a bright signal enhancement and fine anatomic structures in the T1-weighted MR image of a mouse brain (see picture; left MRI, right MnO-enhanced MRI (MONEMRI)). Furthermore, MnO nanoparticles conjugated with a tumor-specific antibody were used for selectively imaging breast cancer cells in a metastatic tumor in brain. (Figure Presented).",

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language = "English",

volume = "46",

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T1 - Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles

AU - Na, Hyon Bin

AU - Lee, Jung Hee

AU - An, Kwangjin

AU - Park, Yong Il

AU - Park, Mihyun

AU - Lee, In Su

AU - Nam, Do Hyun

AU - Kim, Sung Tae

AU - Kim, Seung Hoon

AU - Kim, Sang Wook

AU - Lim, Keun Ho

AU - Kim, Ki Soo

AU - Kim, Sun Ok

AU - Hyeon, Taeghwan

PY - 2007

Y1 - 2007

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AB - Contrasting images: A new T1 contrast agent for magnetic resonance imaging (MRI) based on MnO nanoparticles reveals a bright signal enhancement and fine anatomic structures in the T1-weighted MR image of a mouse brain (see picture; left MRI, right MnO-enhanced MRI (MONEMRI)). Furthermore, MnO nanoparticles conjugated with a tumor-specific antibody were used for selectively imaging breast cancer cells in a metastatic tumor in brain. (Figure Presented).

KW - Contrast agents

KW - Imaging agents

KW - Magnetic resonance imaging

KW - Manganese

KW - Nanoparticles

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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