Development of a disposable kit with fully automatic self-shielding reactor for [18F]FDG synthesis

Seyoung Oh; Kyungrok Nam; Kyo Chul Lee; Mitra Ghergherehchi; Byungil Kim; Jung Young Kim; Ho Seung Song; Jong Seo Chai

doi:10.1016/j.apradiso.2017.10.044

Development of a disposable kit with fully automatic self-shielding reactor for [¹⁸F]FDG synthesis

Seyoung Oh
, Kyungrok Nam
, Kyo Chul Lee
, Mitra Ghergherehchi
, Byungil Kim
, Jung Young Kim
, Ho Seung Song
, Jong Seo Chai

Department of Electronic and Electrical Engineering

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A self-shielding device for the synthesis of radiopharmaceuticals was developed and fabricated in this study. Radiation exposure was minimized by the self-shielding of the kit, installation of the disposable kit in the auxiliary chamber while in a shielded state, and discharge of the kit into a radioactive waste container upon completion of the synthesis process. The developed self-shielding synthesis kit was tested by synthesizing 2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) in order to verify its performance.

Original language	English
Pages (from-to)	23-29
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	131
DOIs	https://doi.org/10.1016/j.apradiso.2017.10.044
State	Published - Jan 2018

Keywords

2-[F]fluoro-2-deoxy-D-glucose
Automated synthesis system
Radiopharmaceuticals
Self-shielding reactor
[F]FDG

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10.1016/j.apradiso.2017.10.044

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title = "Development of a disposable kit with fully automatic self-shielding reactor for [18F]FDG synthesis",

abstract = "A self-shielding device for the synthesis of radiopharmaceuticals was developed and fabricated in this study. Radiation exposure was minimized by the self-shielding of the kit, installation of the disposable kit in the auxiliary chamber while in a shielded state, and discharge of the kit into a radioactive waste container upon completion of the synthesis process. The developed self-shielding synthesis kit was tested by synthesizing 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) in order to verify its performance.",

keywords = "2-[F]fluoro-2-deoxy-D-glucose, Automated synthesis system, Radiopharmaceuticals, Self-shielding reactor, [F]FDG",

author = "Seyoung Oh and Kyungrok Nam and Lee, \{Kyo Chul\} and Mitra Ghergherehchi and Byungil Kim and Kim, \{Jung Young\} and Song, \{Ho Seung\} and Chai, \{Jong Seo\}",

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doi = "10.1016/j.apradiso.2017.10.044",

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journal = "Applied Radiation and Isotopes",

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T1 - Development of a disposable kit with fully automatic self-shielding reactor for [18F]FDG synthesis

AU - Oh, Seyoung

AU - Nam, Kyungrok

AU - Lee, Kyo Chul

AU - Ghergherehchi, Mitra

AU - Kim, Byungil

AU - Kim, Jung Young

AU - Song, Ho Seung

AU - Chai, Jong Seo

PY - 2018/1

Y1 - 2018/1

N2 - A self-shielding device for the synthesis of radiopharmaceuticals was developed and fabricated in this study. Radiation exposure was minimized by the self-shielding of the kit, installation of the disposable kit in the auxiliary chamber while in a shielded state, and discharge of the kit into a radioactive waste container upon completion of the synthesis process. The developed self-shielding synthesis kit was tested by synthesizing 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) in order to verify its performance.

AB - A self-shielding device for the synthesis of radiopharmaceuticals was developed and fabricated in this study. Radiation exposure was minimized by the self-shielding of the kit, installation of the disposable kit in the auxiliary chamber while in a shielded state, and discharge of the kit into a radioactive waste container upon completion of the synthesis process. The developed self-shielding synthesis kit was tested by synthesizing 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) in order to verify its performance.

KW - 2-[F]fluoro-2-deoxy-D-glucose

KW - Automated synthesis system

KW - Radiopharmaceuticals

KW - Self-shielding reactor

KW - [F]FDG

UR - https://www.scopus.com/pages/publications/85032454126

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M3 - Article

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AN - SCOPUS:85032454126

SN - 0969-8043

VL - 131

SP - 23

EP - 29

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Development of a disposable kit with fully automatic self-shielding reactor for [¹⁸F]FDG synthesis

Abstract

Keywords

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