Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats

Sang Kyu Lee; Yoon Kim; Tae Kon Kim; Guang Jin Im; Bong Yong Lee; Dong Hyun Kim; Changbae Jin; Hye Hyun Yoo

doi:10.1016/j.jpba.2008.11.004

Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats

Sang Kyu Lee, Yoon Kim, Tae Kon Kim, Guang Jin Im, Bong Yong Lee, Dong Hyun Kim, Changbae Jin, Hye Hyun Yoo

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The purpose of the present study was to determine sildenafil and a novel PDE-5 inhibitor, mirodenafil in the plasma and corpus cavernosum tissue of rats to compare their pharmacokinetic properties. The concentrations of mirodenafil and sildenafil in the rat plasma and corpus cavernosum tissue samples were analyzed using LC-MS/MS after a single oral administration at a dose of 40 mg/kg to rats. Although the T_max, Tλ_1/2 and MRT were not different between mirodenafil and sildenafil, the C_max and AUC of mirodenafil were significantly higher than those of sildenafil in the plasma and corpus cavernosum tissue. Consequently mirodenafil remained longer than sildenafil in the plasma and tissue. This may provide pharmacokinetic evidence for assessment of the in vivo efficacy of mirodenafil and sildenafil.

Original language	English
Pages (from-to)	513-518
Number of pages	6
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/j.jpba.2008.11.004
State	Published - 20 Feb 2009
Externally published	Yes

Keywords

LC-MS/MS
Mirodenafil
Sildenafil
Tissue distribution

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10.1016/j.jpba.2008.11.004

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title = "Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats",

abstract = "The purpose of the present study was to determine sildenafil and a novel PDE-5 inhibitor, mirodenafil in the plasma and corpus cavernosum tissue of rats to compare their pharmacokinetic properties. The concentrations of mirodenafil and sildenafil in the rat plasma and corpus cavernosum tissue samples were analyzed using LC-MS/MS after a single oral administration at a dose of 40 mg/kg to rats. Although the Tmax, Tλ1/2 and MRT were not different between mirodenafil and sildenafil, the Cmax and AUC of mirodenafil were significantly higher than those of sildenafil in the plasma and corpus cavernosum tissue. Consequently mirodenafil remained longer than sildenafil in the plasma and tissue. This may provide pharmacokinetic evidence for assessment of the in vivo efficacy of mirodenafil and sildenafil.",

keywords = "LC-MS/MS, Mirodenafil, Sildenafil, Tissue distribution",

author = "Lee, \{Sang Kyu\} and Yoon Kim and Kim, \{Tae Kon\} and Im, \{Guang Jin\} and Lee, \{Bong Yong\} and Kim, \{Dong Hyun\} and Changbae Jin and Yoo, \{Hye Hyun\}",

year = "2009",

month = feb,

day = "20",

doi = "10.1016/j.jpba.2008.11.004",

language = "English",

volume = "49",

pages = "513--518",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

issn = "0731-7085",

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TY - JOUR

T1 - Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats

AU - Lee, Sang Kyu

AU - Kim, Yoon

AU - Kim, Tae Kon

AU - Im, Guang Jin

AU - Lee, Bong Yong

AU - Kim, Dong Hyun

AU - Jin, Changbae

AU - Yoo, Hye Hyun

PY - 2009/2/20

Y1 - 2009/2/20

N2 - The purpose of the present study was to determine sildenafil and a novel PDE-5 inhibitor, mirodenafil in the plasma and corpus cavernosum tissue of rats to compare their pharmacokinetic properties. The concentrations of mirodenafil and sildenafil in the rat plasma and corpus cavernosum tissue samples were analyzed using LC-MS/MS after a single oral administration at a dose of 40 mg/kg to rats. Although the Tmax, Tλ1/2 and MRT were not different between mirodenafil and sildenafil, the Cmax and AUC of mirodenafil were significantly higher than those of sildenafil in the plasma and corpus cavernosum tissue. Consequently mirodenafil remained longer than sildenafil in the plasma and tissue. This may provide pharmacokinetic evidence for assessment of the in vivo efficacy of mirodenafil and sildenafil.

AB - The purpose of the present study was to determine sildenafil and a novel PDE-5 inhibitor, mirodenafil in the plasma and corpus cavernosum tissue of rats to compare their pharmacokinetic properties. The concentrations of mirodenafil and sildenafil in the rat plasma and corpus cavernosum tissue samples were analyzed using LC-MS/MS after a single oral administration at a dose of 40 mg/kg to rats. Although the Tmax, Tλ1/2 and MRT were not different between mirodenafil and sildenafil, the Cmax and AUC of mirodenafil were significantly higher than those of sildenafil in the plasma and corpus cavernosum tissue. Consequently mirodenafil remained longer than sildenafil in the plasma and tissue. This may provide pharmacokinetic evidence for assessment of the in vivo efficacy of mirodenafil and sildenafil.

KW - LC-MS/MS

KW - Mirodenafil

KW - Sildenafil

KW - Tissue distribution

UR - https://www.scopus.com/pages/publications/59349093290

U2 - 10.1016/j.jpba.2008.11.004

DO - 10.1016/j.jpba.2008.11.004

M3 - Article

C2 - 19095395

AN - SCOPUS:59349093290

SN - 0731-7085

VL - 49

SP - 513

EP - 518

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

IS - 2

ER -

Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats

Abstract

Keywords

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